产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF9189, RRID:AB_2842385.
展开/折叠
2-dihydrobenzene-1; 2-diol dehydrogenase; 20 alpha (3 alpha) hydroxysteroid dehydrogenase; 20 ALPHA HSD; 20 alpha hydroxysteroid dehydrogenase; 20-alpha-HSD; 20-alpha-hydroxysteroid dehydrogenase; 20ALPHAHSD; 2ALPHAHSD; AK1C1; AK1C1_HUMAN; AKR1C1; Aldo keto reductase family 1 member C1; aldo-keto reductase C; Aldo-keto reductase family 1 member C1; Aldo-keto reductase family, 1 member 1; C9; Chlordecone reductase homolog; Chlordecone reductase homolog HAKRC; DD1; DD1/DD2; DDH; DDH1; Dihydrodiol dehydrogenase 1; Dihydrodiol dehydrogenase 1/2; dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase; dihydrodiol dehydrogenase isoform DD1; Dihydrodiol dehydrogenase, type 1; H37; HAKRC; HBAB; Hepatic dihydrodiol dehydrogenase; High affinity hepatic bile acid-binding protein; High-affinity hepatic bile acid-binding protein; Indanol dehydrogenase; MBAB; MGC8954; Trans-1; Trans-1,2 dihydrobenzene 1,2 diol dehydrogenase; Type II 3 alpha hydroxysteroid dehydrogenase;
抗原和靶标
Expressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain.
- Q04828 AK1C1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY
翻译修饰 - Q04828 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K4 | Acetylation | Uniprot | |
| K4 | Sumoylation | Uniprot | |
| K4 | Ubiquitination | Uniprot | |
| Y5 | Phosphorylation | Uniprot | |
| K9 | Sumoylation | Uniprot | |
| K9 | Ubiquitination | Uniprot | |
| T23 | Phosphorylation | Uniprot | |
| Y24 | Phosphorylation | Uniprot | |
| K31 | Ubiquitination | Uniprot | |
| S32 | Phosphorylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| T38 | Phosphorylation | Uniprot | |
| K39 | Ubiquitination | Uniprot | |
| S51 | Phosphorylation | Uniprot | |
| Y55 | Phosphorylation | Uniprot | |
| S67 | Phosphorylation | Uniprot | |
| K68 | Ubiquitination | Uniprot | |
| S73 | Phosphorylation | Uniprot | |
| K75 | Acetylation | Uniprot | |
| K75 | Sumoylation | Uniprot | |
| K75 | Ubiquitination | Uniprot | |
| Y81 | Phosphorylation | Uniprot | |
| T82 | Phosphorylation | Uniprot | |
| S83 | Phosphorylation | Uniprot | |
| K84 | Ubiquitination | Uniprot | |
| K104 | Sumoylation | Uniprot | |
| K104 | Ubiquitination | Uniprot | |
| Y110 | Phosphorylation | Uniprot | |
| K123 | Ubiquitination | Uniprot | |
| K131 | Sumoylation | Uniprot | |
| T141 | Phosphorylation | Uniprot | |
| K161 | Ubiquitination | Uniprot | |
| S162 | Phosphorylation | Uniprot | |
| S166 | Phosphorylation | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| K183 | Ubiquitination | Uniprot | |
| Y184 | Phosphorylation | Uniprot | |
| K185 | Ubiquitination | Uniprot | |
| Y196 | Phosphorylation | Uniprot | |
| K201 | Ubiquitination | Uniprot | |
| K207 | Ubiquitination | Uniprot | |
| S208 | Phosphorylation | Uniprot | |
| K209 | Ubiquitination | Uniprot | |
| S232 | Phosphorylation | Uniprot | |
| K246 | Acetylation | Uniprot | |
| K246 | Ubiquitination | Uniprot | |
| K247 | Acetylation | Uniprot | |
| K247 | Ubiquitination | Uniprot | |
| K270 | Acetylation | Uniprot | |
| K270 | Ubiquitination | Uniprot | |
| Y272 | Phosphorylation | Uniprot | |
| K294 | Ubiquitination | Uniprot | |
| Y305 | Phosphorylation | Uniprot | |
| Y317 | Phosphorylation | Uniprot |
研究背景
Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.
Cytoplasm.
Expressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain.
Monomer.
Belongs to the aldo/keto reductase family.
研究领域
· Metabolism > Lipid metabolism > Steroid hormone biosynthesis.
· Metabolism > Xenobiotics biodegradation and metabolism > Metabolism of xenobiotics by cytochrome P450.
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