ADAMDEC1 Antibody - #DF9167

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产品: ADAMDEC1 抗体
货号: DF9167
描述: Rabbit polyclonal antibody to ADAMDEC1
应用: WB IHC IF/ICC
文献验证: WB, IF/ICC
反应: Human, Mouse
分子量: 53kDa; 53kD(Calculated).
蛋白号: O15204
RRID: AB_2842363

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse
克隆:
Polyclonal
特异性:
ADAMDEC1 Antibody detects endogenous levels of total ADAMDEC1.
RRID:
AB_2842363
引用格式: Affinity Biosciences Cat# DF9167, RRID:AB_2842363.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

A disintegrin and metalloproteinase domain like protein decysin 1; A disintegrin and metalloproteinase domain-like protein decysin-1; ADAM DEC1; ADAM like decysin 1; ADAM like protein decysin 1; ADAM-like protein decysin-1; ADAMDEC 1; Adamdec1; ADEC1_HUMAN; Decysin; Disintegrin protease; M12.219;

抗原和靶标

免疫原:
Uniprot:

O15204(ADEC1_HUMAN) >>Visit HPA database.

基因/基因ID:
ADAMDEC1(27299)
表达:
O15204 ADEC1_HUMAN:

Expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining of the colon, thymus, spleen and very weakly in the bone marrow. Predominantly expressed in dendritic cells (DC) of the germinal center. Weakly expressed in monocyte and highly expressed in macrophage. Absent in immature DC.

序列:
MLRGISQLPAVATMSWVLLPVLWLIVQTQAIAIKQTPELTLHEIVCPKKLHILHKREIKNNQTEKHGKEERYEPEVQYQMILNGEEIILSLQKTKHLLGPDYTETLYSPRGEEITTKPENMEHCYYKGNILNEKNSVASISTCDGLRGYFTHHHQRYQIKPLKSTDEKEHAVFTSNQEEQDPANHTCGVKSTDGKQGPIRISRSLKSPEKEDFLRAQKYIDLYLVLDNAFYKNYNENLTLIRSFVFDVMNLLNVIYNTIDVQVALVGMEIWSDGDKIKVVPSASTTFDNFLRWHSSNLGKKIHDHAQLLSGISFNNRRVGLAASNSLCSPSSVAVIEAKKKNNVALVGVMSHELGHVLGMPDVPFNTKCPSGSCVMNQYLSSKFPKDFSTSCRAHFERYLLSQKPKCLLQAPIPTNIMTTPVCGNHLLEVGEDCDCGSPKECTNLCCEALTCKLKPGTDCGGDAPNHTTE

研究背景

功能:

May play an important role in the control of the immune response and during pregnancy.

细胞定位:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining of the colon, thymus, spleen and very weakly in the bone marrow. Predominantly expressed in dendritic cells (DC) of the germinal center. Weakly expressed in monocyte and highly expressed in macrophage. Absent in immature DC.

文献引用

1). ADAMDEC1 promotes skin inflammation in rosacea via modulating the polarization of M1 macrophages. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020 (PubMed: 31627897) [IF=2.5]

Application: IF/ICC    Species: mouse    Sample: macrophages

Fig. 2. ADAMDEC1 was located at macrophages and upregulated in M1 macrophages. (A) Co-localization of F4/80 and ADAMDEC1 in sections from LL37-induced mice model.

Application: WB    Species: mouse    Sample: macrophages

Fig. 3. |Knocking down of ADAMDEC1 impeded M1 macrophage activation. Macrophages were transfected with ADAMDEC1 siRNA (siAdam-1 and siAdam-2) (n ¼ 3) and negative control siRNA (siCtrl) (n ¼ 3) separately for 48 h. (A) ADAMDEC1 protein and mRNA level were detected in transfected human monocyte-derived macrophages.

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