PDCD6IP Antibody - #DF9027

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产品: PDCD6IP 抗体
货号: DF9027
描述: Rabbit polyclonal antibody to PDCD6IP
应用: WB
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Rabbit, Dog, Chicken, Xenopus
蛋白号: Q8WUM4
RRID: AB_2842223

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
PDCD6IP Antibody detects endogenous levels of total PDCD6IP.
RRID:
AB_2842223
引用格式: Affinity Biosciences Cat# DF9027, RRID:AB_2842223.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

AIP1; ALG 2 interacting protein 1; ALG-2-interacting protein 1; ALG2 interacting protein X; Alix; Apoptosis linked gene 2 interacting protein X; Dopamine receptor interacting protein 4; DRIP4; Hp95; KIAA1375; MGC17003; PDC6I_HUMAN; PDCD6 interacting protein; PDCD6-interacting protein; PDCD6IP; Programmed cell death 6 interacting protein; Programmed cell death 6-interacting protein;

抗原和靶标

免疫原:

A synthesized peptide derived from human PDCD6IP, corresponding to a region within N-terminal amino acids.

基因/基因ID:
PDCD6IP(10015)

研究领域

· Cellular Processes > Transport and catabolism > Endocytosis.   (View pathway)

文献引用

1). M2-like macrophage-derived exosomes facilitate metastasis in non-small-cell lung cancer by delivering integrin αVβ3. MedComm, 2022 (PubMed: 36582304) [IF=9.9]
2). Endometrial extracellular vesicles from women with recurrent implantation failure attenuate the growth and invasion of embryos. FERTILITY AND STERILITY, 2020 (PubMed: 32622655) [IF=6.6]

Application: WB    Species: Human    Sample: RIF-EVs and FER-EVs.

Figure 1.Isolation of EVs and determination of RIF-EVs and FER-EVs. (A) Western blotting shows that RIF-EVs and FER-EVs expressed classic EV protein markers Alix, TSG101, and CD9. Representative shapes of (B) RIF-EVs and (C) FER-EVs detected with the use of transmission electron microscopy. The size and distribution of (D) RIF-EVs and (E) FER-EVs examined with the use of nanoparticle tracking analysis. ECs ¼ endometrial cells; EVs ¼ extracellular vesicles; FER ¼ fertile women; RIF ¼ women with recurrent implantation failure. Liu. Extracellular vesicles regulate embryos. Fertil Steril 2020.
3). Mesenchymal stem cell-derived exosome mitigates colitis via the modulation of the gut metagenomics–metabolomics–farnesoid X receptor axis. Biomaterials Science, 2022 (PubMed: 35858469) [IF=5.8]
4). Discovery and validation of extracellular vesicle‐associated miRNAs as noninvasive detection biomarkers for early‐stage non‐small‐cell lung cancer. Molecular Oncology, 2021 (PubMed: 33340250) [IF=5.0]

Application: WB    Species: Human    Sample: lung tissues

Figure 1. Characterisation of EVs derived from the serum and plasma of NSCLC patients and controls. (a) The shape and structure of serum and plasma EVs isolated by EXOquick kit under TEM. The red arrow represents EVs with typical characteristics (scale bars are 200 nm). (b) The size of EVs derived from control groups and NSCLC groups was analysed by NTA. (c) Western blots of EVs membrane markers, including Alix, CD63, TSG101, CD9, and one negative marker ALB.
5). Bone marrow mesenchymal stem cells-derived exosomes ameliorate LPS-induced acute lung injury by miR-223-regulated alveolar macrophage M2 polarization. Journal of biochemical and molecular toxicology, 2024 (PubMed: 37899695) [IF=3.2]
6). Pericardial Administration of Extracellular Vesicles Derived from Bone Marrow Stem Cells Improved Doxorubicin-induced Heart Failure with Mid Range Ejection Fraction (HFmrEF) in Rats. Cardiovascular drugs and therapy, 2025 (PubMed: 40498225) [IF=3.1]
7). Human Umbilical Cord Mesenchymal Stem Cells Improve Ovarian Function in Chemotherapy-Induced Premature Ovarian Failure Mice Through Inhibiting Apoptosis and Inflammation via a Paracrine Mechanism. Reproductive Sciences, 2021 (PubMed: 33751459) [IF=2.6]

Application: WB    Species: Human    Sample: granulosa cells

Fig. 6 Identification of UC-MSC-EVs and effects of UC-MSC-EVs on NM-treated granulosa cells in vitro. a Nanoparticle tracking analysis, b the image under transmission electron microscope, and c the protein expression of EV markers for EVs extracted from UC-MSCs culture medium. After NM-KGN cells treated with or without UC-MSC-EVs for 48 h, d the morphology of KGN cells was observed, and e the survival rates were examined by CCK-8 assays. f The IL-6 and IL-1β concentrations of NM-KGN cells (adjusted by the protein concentrations) treated with or without UC-MSC-EVs. g Flow cytometric analysis of AnnexinV/ PI staining levels of KGN cells. h Comparisons of total, early and late apoptosis rates of KGN cells among the three groups. *P < 0.05. **P < 0.01
8). Altered microRNA Profiles of Extracellular Vesicles Secreted by Endometrial Cells from Women with Recurrent Implantation Failure. Reproductive sciences (Thousand Oaks, Calif.), 2021 (PubMed: 33432533) [IF=2.6]
9). Pancreatic Cancer-Derived Exosomes Promote the Proliferation, Invasion, and Metastasis of Pancreatic Cancer by the miR-3960/TFAP2A Axis. Journal of Oncology, 2022 (PubMed: 36284637)

Application: WB    Species: Mice    Sample:

Figure 2 The identification of PANC-1-derived exosomes. (x¯¯±s, n =3). (a) Transmission electron microscopy. (Scale bar =200 nm) (b and c) Nanoparticle Tracking analysis. (d) The average levels of TSG101, Alix, CD81, CD9, CD63, HSP70 and C-myc. ∗∗P <0.01 compared to the cell group.

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