| 产品: | CDCA7L 抗体 |
| 货号: | DF8916 |
| 描述: | Rabbit polyclonal antibody to CDCA7L |
| 应用: | WB IHC |
| 反应: | Human |
| 预测: | Pig, Sheep |
| 分子量: | 52 kDa; 52kD(Calculated). |
| 蛋白号: | Q96GN5 |
| RRID: | AB_2842112 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8916, RRID:AB_2842112.
展开/折叠
c Myc Interacting protein JPO2; CDCA7L; DKFZp762L0311; HR1; JPO2; Protein JPO2; R1; RAM2; Transcription Factor RAM2;
抗原和靶标
- Q96GN5 CDA7L_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MELATRYQIPKEVADIFNAPSDDEEFVGFRDDVPMETLSSEESCDSFDSLESGKQQDVRFHSKYFTEELRRIFIEDTDSETEDFAGFTQSDLNGKTNPEVMVVESDLSDDGKASLVSEEEEDEEEDKATPRRSRSRRSSIGLRVAFQFPTKKLANKPDKNSSSEQLFSSARLQNEKKTILERKKDCRQVIQREDSTSESEDDSRDESQESSDALLKRTMNIKENKAMLAQLLAELNSMPDFFPVRTPTSASRKKTVRRAFSEGQITRRMNPTRSARPPEKFALENFTVSAAKFAEEFYSFRRRKTIGGKCREYRRRHRISSFRPVEDITEEDLENVAITVRDKIYDKVLGNTCHQCRQKTIDTKTVCRNQGCCGVRGQFCGPCLRNRYGEDVRSALLDPDWVCPPCRGICNCSYCRKRDGRCATGILIHLAKFYGYDNVKEYLESLQKELVEDN
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
研究背景
Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.
Phosphorylation increases its interaction with PSIP1.
Cytoplasm. Nucleus.
Note: Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.
Ubiquitous. Overexpressed in medulloblastoma.
Interacts with MYC. Interacts (via IBM motifs) with PSIP1 (via IBD domain); phosphorylation increases its affinity for PSIP1.
限制条款
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