| 产品: | PINX1 抗体 |
| 货号: | DF8858 |
| 描述: | Rabbit polyclonal antibody to PINX1 |
| 应用: | WB IHC |
| 反应: | Human, Mouse |
| 预测: | Pig, Rabbit |
| 分子量: | 37 kDa; 37kD(Calculated). |
| 蛋白号: | Q96BK5 |
| RRID: | AB_2842055 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8858, RRID:AB_2842055.
展开/折叠
67-11-3 protein; FLJ20565; Hepatocellular carcinoma-related putative tumor suppressor; Liver-related putative tumor suppressor; LPTL; LPTS; MGC8850; OTTHUMP00000224984; OTTHUMP00000224985; OTTHUMP00000224986; OTTHUMP00000225053; OTTHUMP00000225054; PIN2 interacting protein 1; Pin2-interacting protein X1; PIN2/TERF1-interacting telomerase inhibitor 1; PINX1; PINX1_HUMAN; Protein 67-11-3; TRF1-interacting protein 1;
抗原和靶标
Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.
- Q96BK5 PINX1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSMLAERRRKQKWAVDPQNTAWSNDDSKFGQRMLEKMGWSKGKGLGAQEQGATDHIKVQVKNNHLGLGATINNEDNWIAHQDDFNQLLAELNTCHGQETTDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKGKDLSSRSKTDLDCIFGKRQSKKTPEGDASPSTPEENETTTTSAFTIQEYFAKRMAALKNKPQVPVPGSDISETQVERKRGKKRNKEATGKDVESYLQPKAKRHTEGKPERAEAQERVAKKKSAPAEEQLRGPCWDQSSKASAQDAGDHVQPPEGRDFTLKPKKRRGKKKLQKPVEIAEDATLEETLVKKKKKKDSK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
研究背景
Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.
Nucleus. Nucleus>Nucleolus. Chromosome>Telomere. Chromosome>Centromere>Kinetochore.
Note: Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.
Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.
Interacts with MCRS1, TERT, TERF1, NCL/nucleolin, and the telomerase RNA.
The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity.
The TBM domain mediates interaction with TERF1.
Belongs to the PINX1 family.
限制条款
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