| 产品: | JTB 抗体 |
| 货号: | DF8670 |
| 描述: | Rabbit polyclonal antibody to JTB |
| 应用: | WB IF/ICC |
| 反应: | Human |
| 预测: | Pig, Bovine, Sheep, Rabbit |
| 分子量: | 16 kDa; 16kD(Calculated). |
| 蛋白号: | O76095 |
| RRID: | AB_2841874 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8670, RRID:AB_2841874.
展开/折叠
hJT; HJTB; HSPC222; JTB; JTB_HUMAN; Jumping translocation breakpoint; Jumping translocation breakpoint protein; OTTHUMP00000034759; PAR; PAR protein; Prostate androgen regulated protein; Prostate androgen-regulated protein; Protein JTB;
抗原和靶标
Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts.
- O76095 JTB_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLAGAGRPGLPQGRHLCWLLCAFTLKLCQAEAPVQEEKLSASTSNLPCWLVEEFVVAEECSPCSNFRAKTTPECGPTGYVEKITCSSSKRNEFKSCRSALMEQRLFWKFEGAVVCVALIFACLVIIRQRQLDRKALEKVRKQIESI
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
研究背景
Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).
Membrane>Single-pass type I membrane protein. Mitochondrion. Cytoplasm. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Cytoplasm>Cytoskeleton>Spindle.
Note: Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.
Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts.
Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B.
Belongs to the JTB family.
限制条款
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