MGLL Antibody - #DF8444

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产品: MGLL 抗体
货号: DF8444
描述: Rabbit polyclonal antibody to MGLL
应用: WB IHC IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Horse, Sheep, Rabbit, Dog, Chicken
分子量: 33 kDa; 33kD(Calculated).
蛋白号: Q99685
RRID: AB_2841687

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
IF/ICC 1:100-1:500, WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(90%), Zebrafish(90%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(90%), Chicken(90%)
克隆:
Polyclonal
特异性:
MGLL Antibody detects endogenous levels of total MGLL.
RRID:
AB_2841687
引用格式: Affinity Biosciences Cat# DF8444, RRID:AB_2841687.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

EC 3.1.1.23; HU K5; HU-K5; HUK5; Lysophospholipase homolog; Lysophospholipase like; Lysophospholipase-like; MAGL; MGL; MGLL; MGLL_HUMAN; Monoacylglycerol lipase; Monoglyceride lipase;

抗原和靶标

免疫原:
Uniprot:

Q99685(MGLL_HUMAN) >>Visit HPA database.

基因/基因ID:
MGLL(11343)
表达:
Q99685 MGLL_HUMAN:

Detected in adipose tissue, lung, liver, kidney, brain and heart.

序列:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Horse
100
Sheep
100
Rabbit
100
Pig
90
Dog
90
Zebrafish
90
Chicken
90
Xenopus
60
Bovine
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q99685 作为底物

Site PTM Type Enzyme
T10 Phosphorylation
K36 Ubiquitination
K188 Ubiquitination
T189 Phosphorylation
S196 Phosphorylation
Y248 Phosphorylation
S301 Phosphorylation

研究背景

功能:

Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.

细胞定位:

Cytoplasm>Cytosol. Membrane>Peripheral membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Detected in adipose tissue, lung, liver, kidney, brain and heart.

亚基结构:

Homodimer.

蛋白家族:

Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family.

研究领域

· Metabolism > Lipid metabolism > Glycerolipid metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Nervous system > Retrograde endocannabinoid signaling.   (View pathway)

· Organismal Systems > Endocrine system > Regulation of lipolysis in adipocytes.

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