MUC2 Antibody - #DF8390

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产品: MUC2 抗体
货号: DF8390
描述: Rabbit polyclonal antibody to MUC2
应用: WB IHC IF/ICC
文献验证: WB, IHC, IF/ICC
反应: Human, Mouse, Rat
预测: Bovine, Rabbit
蛋白ID: Q02817
RRID: AB_2827875

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
MUC2 Antibody detects endogenous levels of total MUC2.
RRID:
AB_2827875
引用格式: Affinity Biosciences Cat# DF8390, RRID:AB_2827875.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Intestinal mucin 2; Intestinal mucin-2; MLP; MUC 2; MUC-2; Muc2; MUC2_HUMAN; Mucin 2; Mucin 2 intestinal; Mucin 2 intestinal/tracheal; Mucin 2 oligomeric mucus/gel forming; Mucin 2 precursor; Mucin 2 tracheal; Mucin like protein; Mucin-2; Mucin2; SMUC;

抗原和靶标

免疫原:

A synthesized peptide derived from human MUC2, corresponding to a region within N-terminal amino acids.

文献引用

1). A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon. Acta Biomaterialia, 2022 (PubMed: 35245681) [IF=9.4]
2). Fourteen composite probiotics alleviate type 2 diabetes through modulating gut microbiota and modifying M1/M2 phenotype macrophage in db/ db mice. PHARMACOLOGICAL RESEARCH, 2020 (PubMed: 32818655) [IF=9.1]

Application: IHC    Species: mouse    Sample: colon

Fig. 4.| Effects of the composite probiotics on intestinal barrier function.The protein expression of claudin-1 (G), occludin-1 (H), ZO-1 (I) and mucin-2 (J)determined by immunohistochemistry (original magnification 200×) (n = 4 images/group).
3). Feedback delivery of BMP 7 on the pathological oxidative stress via smart hyaluronic acid hydrogel potentiated the repairing of the gut epithelial integrity. International journal of biological macromolecules, 2024 (PubMed: 39447783) [IF=7.7]
4). Tremella fuciformis polysaccharides ameliorated ulcerative colitis via inhibiting inflammation and enhancing intestinal epithelial barrier function. International Journal of Biological Macromolecules, 2021 (PubMed: 33744251) [IF=7.7]

Application: IF/ICC    Species: human    Sample: Caco-2 cells

Fig. 7.| Effect of Tremella fuciformis polysaccharides on regulating the expressions of proteins for intestinal barrier and mucus barrier in LPS-stimulated Caco-2 cells. s. (A) Representative fluorescent images of ZO-1 in Caco-2 cells. (B) The fluorescence intensity of ZO-1 in Caco-2 cells. (C) Representative fluorescent images of occludin in Caco-2 cells. (D) The fluorescence intensity of occludin in Caco-2 cells. (E) Representative fluorescent images of Muc-2 in Caco-2 cells.
5). Commensal cow Roseburia reduces gut-dysbiosis-induced mastitis through inhibiting bacterial translocation by producing butyrate in mice. Cell Reports, 2022 (PubMed: 36417859) [IF=7.5]

Application: IHC    Species: Mouse    Sample:

Figure 2FMT from cows with mastitis to mice induces mastitis and disrupts the blood-milk and gut barrier in mice
6). Composite probiotics alleviate type 2 diabetes by regulating intestinal microbiota and inducing GLP-1 secretion in db/db mice. BIOMEDICINE & PHARMACOTHERAPY, 2020 (PubMed: 32035395) [IF=6.9]

Application: IHC    Species: Mice    Sample: colon tissue

Fig. 6. The composite probiotics improved intestinal mucosal barrier function. (A, B) The colon histology in HE staining (original magnification 100 × and 200 ×) (n = 4 images/group). (C, D) The claudin-1 (original magnification 200 ×) and mucin-2 (original magnification 400 ×) protein expression of the colon tissue in immunohistochemistry staining (n = 4 images/group). (E, F) The mRNA levels of claudin-1 and mucin-2 in the colon tissue were determined by qRT-PCR (n = 5). (G, H) The levels of LPS in the faeces and serum were determined by ELISA kits (n = 6). Mean integral optical density values of claudin-1 and mucin-2 were analyzed by Image-Pro Plus 6.0. Data are presented as mean ± SD values. ## P < 0.01 vs normal group; * P < 0.05, ** P < 0.01 vs model group.
7). Yiqi Huayu Jiedu formula inhibits JAK2/STAT3-mediated partial EMT in treating chronic atrophic gastritis. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2025 (PubMed: 39799895) [IF=6.7]

Application: IF/ICC    Species: human    Sample: GES-1 cells

Fig. 4. CDCA induced precancerous gastric disease phenotype in GES-1 cells. (A) Morphological changes in cell morphology of GES-1 cells treated with CDCA at different concentrations. (B) Protein expression levels of CDX2, KLF4, Villin in GES-1 cells treated with CDCA. (C) Cellular Immunofluorescent assay were performed on GES-1 cells treated with 400 µM CDCA for 24 h to assess the expression and localization of MUC2 and Villin.
8). Oat Peptides Alleviate Dextran Sulfate Sodium Salt-Induced Colitis by Maintaining the Intestinal Barrier and Modulating the Keap1-Nrf2 Axis. Nutrients, 2023 (PubMed: 38140314) [IF=5.9]

Application: IHC    Species: Mouse    Sample: colon tissue

Figure 3 OPs repair the intestinal mechanical barrier. (A) HE staining results of colon tissue; (B) AB staining results; (C) PAS staining results; (D) IHC results for Muc2 protein; (E) mRNA expression of ZO-1, occludin and claudin 1; (F) Western blotting results for ZO-1, occludin and claudin 1; (G) normalized analysis results for the ZO-1, occludin and claudin 1 proteins. Data are presented as mean ± SD (A–D,G) (n = 3–5 per group).
9). Fucoxanthin Alleviates Dextran Sulfate Sodium-Induced Colitis and Gut Microbiota Dysbiosis in Mice. Journal of agricultural and food chemistry, 2024 (PubMed: 38355398) [IF=5.7]
10). Vitamin D3 mediates amelioration of ulcerative colitis via the TRPV1-MAPK signaling pathway. Frontiers in immunology, 2026 (PubMed: 41694350) [IF=5.7]
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