产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8361, RRID:AB_2841626.
展开/折叠
58 kDa microspherule protein; Cell cycle regulated factor (78 kDa); Cell cycle regulated factor p78; Cell cycle-regulated factor p78; ICP22BP; INO80 complex subunit J; MCRS 1; MCRS 2; MCRS1; MCRS1_HUMAN; MCRS2; Microspherule protein 1; MSP 58; MSP58; p78;
抗原和靶标
Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine, colon and leukocytes.
- Q96EZ8 MCRS1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDKDSQGLLDSSLMASGTASRSEDEESLAGQKRASSQALGTIPKRRSSSRFIKRKKFDDELVESSLAKSSTRAKGASGVEPGRCSGSEPSSSEKKKVSKAPSTPVPPSPAPAPGLTKRVKKSKQPLQVTKDLGRWKPADDLLLINAVLQTNDLTSVHLGVKFSCRFTLREVQERWYALLYDPVISKLACQAMRQLHPEAIAAIQSKALFSKAEEQLLSKVGSTSQPTLETFQDLLHRHPDAFYLARTAKALQAHWQLMKQYYLLEDQTVQPLPKGDQVLNFSDAEDLIDDSKLKDMRDEVLEHELMVADRRQKREIRQLEQELHKWQVLVDSITGMSSPDFDNQTLAVLRGRMVRYLMRSREITLGRATKDNQIDVDLSLEGPAWKISRKQGVIKLKNNGDFFIANEGRRPIYIDGRPVLCGSKWRLSNNSVVEIASLRFVFLINQDLIALIRAEAAKITPQ
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - Q96EZ8 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S20 | Phosphorylation | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| S27 | Phosphorylation | Uniprot | |
| K32 | Acetylation | Uniprot | |
| S35 | Phosphorylation | Uniprot | |
| S36 | Phosphorylation | Uniprot | |
| S48 | Phosphorylation | Uniprot | |
| K56 | Sumoylation | Uniprot | |
| K74 | Methylation | Uniprot | |
| S85 | Phosphorylation | Uniprot | |
| S98 | Phosphorylation | Uniprot | |
| S102 | Phosphorylation | Uniprot | |
| T103 | Phosphorylation | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| T116 | Phosphorylation | Uniprot | |
| K117 | Ubiquitination | Uniprot | |
| K123 | Acetylation | Uniprot | |
| K130 | Acetylation | Uniprot | |
| K130 | Ubiquitination | Uniprot | |
| K206 | Ubiquitination | Uniprot | |
| K211 | Ubiquitination | Uniprot | |
| K219 | Ubiquitination | Uniprot | |
| S282 | Phosphorylation | Uniprot | |
| K292 | Ubiquitination | Uniprot | |
| K370 | Ubiquitination | Uniprot | |
| K397 | Ubiquitination | Uniprot | |
| K458 | Ubiquitination | Uniprot | |
| T460 | Phosphorylation | Uniprot |
研究背景
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity. Binds to G-quadruplex structures in mRNA. Binds to RNA homopolymer poly(G) and poly(U).
Nucleus. Nucleus>Nucleolus. Cytoplasm.
Note: In microspherules in the nucleolus.
Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine, colon and leukocytes.
Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts with NOP2. Interacts with PINX1. Interacts with TERT. Interacts with CCDC85B. Interacts with DAXX. Interacts (via N-terminus) with FMR1 (via phosphorylated form). Interacts with FXR1 AND FXR2.
(Microbial infection) Interacts with Herpes simplex virus ICP22.
研究领域
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
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