TXNRD1 Antibody - #DF8339

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产品: TXNRD1 抗体
货号: DF8339
描述: Rabbit polyclonal antibody to TXNRD1
应用: WB IHC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 55 kDa; 71kD(Calculated).
蛋白号: Q16881
RRID: AB_2841607

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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MS Report
HPLC Report
MSDS
说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Bovine(100%), Horse(92%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%), Xenopus(100%)
克隆:
Polyclonal
特异性:
TXNRD1 Antibody detects endogenous levels of total TXNRD1.
RRID:
AB_2841607
引用格式: Affinity Biosciences Cat# DF8339, RRID:AB_2841607.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

cytoplasmic; Gene associated with retinoic and IFN-induced mortality 12 protein; Gene associated with retinoic and interferon-induced mortality 12 protein; Gene associated with retinoid IFN induced mortality 12 protein; GRIM 12; GRIM-12; GRIM12; KDRF; KM 102 derived reductase like factor; KM-102-derived reductase-like factor; MGC9145; Oxidoreductase; Thioredoxin reductase 1; Thioredoxin reductase 1 cytoplasmic; Thioredoxin reductase GRIM 12; Thioredoxin reductase TR1; TR 1; TR; TR1; TRXR 1; TRXR1; TRXR1_HUMAN; TXNR; TXNRD 1; Txnrd1;

抗原和靶标

免疫原:

A synthesized peptide derived from human TXNRD1, corresponding to a region within the internal amino acids.

Uniprot:

Q16881(TRXR1_HUMAN) >>Visit HPA database.

基因/基因ID:
TXNRD1(7296)
表达:
Q16881 TRXR1_HUMAN:

Isoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines. Isoform 4 is widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver.

序列:
MGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQAYIDGHSVVIFSRSTCTRCTEVKKLFKSLCVPYFVLELDQTEDGRALEGTLSELAAETDLPVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCUG

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Chicken
100
Rabbit
100
Horse
92
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q16881 作为底物

Site PTM Type Enzyme
T39 Phosphorylation
T50 Phosphorylation
K126 Ubiquitination
K129 Ubiquitination
K138 Methylation
K138 Ubiquitination
K147 Ubiquitination
K150 Methylation
S160 Phosphorylation
Y161 Phosphorylation
Y163 Phosphorylation
K179 Ubiquitination
Y184 Phosphorylation
K187 Ubiquitination
T195 Phosphorylation
T197 Phosphorylation
K217 Ubiquitination
K218 Ubiquitination
K239 Acetylation
K239 Ubiquitination
K245 Acetylation
K245 Ubiquitination
K274 Ubiquitination
Y277 Phosphorylation
Y281 Phosphorylation
K291 Ubiquitination
K298 Acetylation
K300 Ubiquitination
K324 Ubiquitination
K385 Ubiquitination
K396 Ubiquitination
K405 Acetylation
K405 Sumoylation
K405 Ubiquitination
T413 Phosphorylation
Y434 Phosphorylation
K449 Ubiquitination
K458 Ubiquitination
K462 Ubiquitination
K465 Ubiquitination
T469 Phosphorylation
T474 Phosphorylation
Y478 Phosphorylation
K489 Ubiquitination
T493 Phosphorylation
K514 Ubiquitination
K539 Ubiquitination
Y555 Phosphorylation
Y572 Phosphorylation
K574 Ubiquitination
K580 Ubiquitination
K607 Ubiquitination
K613 Ubiquitination
C647 S-Nitrosylation

研究背景

功能:

Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.

翻译修饰:

The N-terminus of isoform 5 is blocked.

ISGylated.

细胞定位:

Cytoplasm.

Cytoplasm. Nucleus.

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Isoform 1 is expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines. Isoform 4 is widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver.

亚基结构:

Homodimer. Isoform 4 interacts with ESR1 and ESR2. Interacts with HERC5.

蛋白家族:

The N-terminal glutaredoxin domain found in isoform 1 does not contain the C-P-Y-C redox-active motif normally found in glutaredoxins and has been found to be inactive in classical glutaredoxin assays.

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

研究领域

· Human Diseases > Cancers: Overview > Pathways in cancer.   (View pathway)

· Human Diseases > Cancers: Specific types > Hepatocellular carcinoma.   (View pathway)

· Metabolism > Metabolism of other amino acids > Selenocompound metabolism.

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