| 产品: | DUSP3 抗体 |
| 货号: | DF8238 |
| 描述: | Rabbit polyclonal antibody to DUSP3 |
| 应用: | WB IHC |
| 反应: | Human, Mouse |
| 预测: | Pig, Bovine, Dog, Chicken |
| 分子量: | 20 kDa; 20kD(Calculated). |
| 蛋白号: | P51452 |
| RRID: | AB_2841534 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8238, RRID:AB_2841534.
展开/折叠
Dual specificity phosphatase 3; Dual specificity protein phosphatase 3; Dual specificity protein phosphatase VHR; DUS3_HUMAN; DUSP3; Serine/threonine specific protein phosphatase; Vaccinia H1-related phosphatase; Vaccinia virus phosphatase VH1 related; VHR;
抗原和靶标
- P51452 DUS3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P51452 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S8 | Phosphorylation | Uniprot | |
| Y38 | Phosphorylation | P43403 (ZAP70) , P43405 (SYK) | Uniprot |
| K50 | Acetylation | Uniprot | |
| K50 | Ubiquitination | Uniprot | |
| K53 | Ubiquitination | Uniprot | |
| S67 | Phosphorylation | Uniprot | |
| S81 | Phosphorylation | Uniprot | |
| T93 | Phosphorylation | Uniprot | |
| Y101 | Phosphorylation | Uniprot | |
| K116 | Ubiquitination | Uniprot | |
| Y138 | Phosphorylation | P43403 (ZAP70) , P43405 (SYK) , P29597 (TYK2) | Uniprot |
| S149 | Phosphorylation | Uniprot |
研究背景
Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.
Nucleus.
Interacts with VRK3, which seems to activate it's phosphatase activity.
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
研究领域
· Environmental Information Processing > Signal transduction > MAPK signaling pathway. (View pathway)
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