| 产品: | IgG1 抗体 |
| 货号: | DF8170 |
| 描述: | Rabbit polyclonal antibody to IgG1 |
| 应用: | WB IF/ICC |
| 反应: | Human |
| 分子量: | 36kDa; 36kD(Calculated). |
| 蛋白号: | P01857 |
| RRID: | AB_2841490 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8170, RRID:AB_2841490.
展开/折叠
Ig gamma 1 chain C region; IgG heavy chain locus; IGHG1; Immunoglobulin Gm1; Immunoglobulin heavy constant gamma 1 (G1m marker);
抗原和靶标
- P01857 IGHG1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
翻译修饰 - P01857 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S7 | Phosphorylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| T18 | Phosphorylation | Uniprot | |
| S19 | Phosphorylation | Uniprot | |
| T22 | Phosphorylation | Uniprot | |
| C27 | S-Nitrosylation | Uniprot | |
| T133 | Phosphorylation | Uniprot | |
| S137 | Phosphorylation | Uniprot | |
| C144 | S-Nitrosylation | Uniprot | |
| N180 | N-Glycosylation | Uniprot | |
| S247 | Phosphorylation | Uniprot | |
| T249 | Phosphorylation | Uniprot | |
| S323 | Phosphorylation | Uniprot | |
| S325 | Phosphorylation | Uniprot | |
| S327 | Phosphorylation | Uniprot |
研究背景
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.
Secreted. Cell membrane.
Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
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