| 产品: | NRG3 抗体 |
| 货号: | DF8144 |
| 描述: | Rabbit polyclonal antibody to NRG3 |
| 应用: | WB IHC |
| 反应: | Human, Mouse |
| 预测: | Rabbit, Dog |
| 分子量: | 56 kDa; 78kD(Calculated). |
| 蛋白号: | P56975 |
| RRID: | AB_2841476 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF8144, RRID:AB_2841476.
展开/折叠
HRG3; Neuregulin 3; Neuregulin 3 like polypeptide; Neuregulin-3; Neuregulin3; NRG-3; Nrg3; NRG3_HUMAN; Pro neuregulin 3; pro NRG3; Pro-NRG3;
抗原和靶标
Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes.
- P56975 NRG3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSEGAAAASPPGAASAAAASAEEGTAAAAAAAAAGGGPDGGGEGAAEPPRELRCSDCIVWNRQQTWLCVVPLFIGFIGLGLSLMLLKWIVVGSVKEYVPTDLVDSKGMGQDPFFLSKPSSFPKAMETTTTTTSTTSPATPSAGGAASSRTPNRISTRLTTITRAPTRFPGHRVPIRASPRSTTARNTAAPATVPSTTAPFFSSSTLGSRPPVPGTPSTQAMPSWPTAAYATSSYLHDSTPSWTLSPFQDAASSSSSSSSSATTTTPETSTSPKFHTTTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLTGSHKHCRCKEGYQGVRCDQFLPKTDSILSDPTDHLGIEFMESEEVYQRQVLSISCIIFGIVIVGMFCAAFYFKSKKQAKQIQEQLKVPQNGKSYSLKASSTMAKSENLVKSHVQLQNYSKVERHPVTALEKMMESSFVGPQSFPEVPSPDRGSQSVKHHRSLSSCCSPGQRSGMLHRNAFRRTPPSPRSRLGGIVGPAYQQLEESRIPDQDTIPCQGIEVRKTISHLPIQLWCVERPLDLKYSSSGLKTQRNTSINMQLPSRETNPYFNSLEQKDLVGYSSTRASSVPIIPSVGLEETCLQMPGISEVKSIKWCKNSYSADVVNVSIPVSDCLIAEQQEVKILLETVQEQIRILTDARRSEDYELASVETEDSASENTAFLPLSPTAKSEREAQFVLRNEIQRDSALTK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - P56975 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S116 | Phosphorylation | Uniprot | |
| S119 | Phosphorylation | Uniprot | |
| T156 | Phosphorylation | Uniprot | |
| S254 | Phosphorylation | Uniprot | |
| S255 | Phosphorylation | Uniprot | |
| S256 | Phosphorylation | Uniprot | |
| S257 | Phosphorylation | Uniprot | |
| T276 | O-Glycosylation | Uniprot | |
| T277 | O-Glycosylation | Uniprot | |
| T278 | O-Glycosylation | Uniprot | |
| S280 | O-Glycosylation | Uniprot | |
| T281 | O-Glycosylation | Uniprot | |
| Y357 | Phosphorylation | Uniprot | |
| Y405 | Phosphorylation | Uniprot | |
| S410 | Phosphorylation | Uniprot | |
| T609 | Phosphorylation | Uniprot |
研究背景
Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.
Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
Extensive glycosylation precedes the proteolytic cleavage (By similarity). Isoform 3 is glycosylated.
Cell membrane>Single-pass type I membrane protein.
Note: Does not seem to be active.
Secreted.
Cell membrane>Single-pass type I membrane protein.
Note: Isoform 3 is also proteolytically released as a soluble form.
Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes.
Interacts with ERBB4.
The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization (By similarity).
ERBB receptor binding is elicited entirely by the EGF-like domain.
Belongs to the neuregulin family.
研究领域
· Environmental Information Processing > Signal transduction > ErbB signaling pathway. (View pathway)
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