PCYT1A Antibody - #DF7927

(2)  
产品: PCYT1A 抗体
货号: DF7927
描述: Rabbit polyclonal antibody to PCYT1A
应用: WB IHC
反应: Human
预测: Bovine, Horse, Sheep, Dog, Chicken, Xenopus
分子量: 42 kDa; 42kD(Calculated).
蛋白号: P49585
RRID: AB_2841339

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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MS Report
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实验方案
WB Handbook
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产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
预测:
Bovine(100%), Horse(100%), Sheep(100%), Dog(100%), Chicken(100%), Xenopus(100%)
克隆:
Polyclonal
特异性:
PCYT1A Antibody detects endogenous levels of total PCYT1A.
RRID:
AB_2841339
引用格式: Affinity Biosciences Cat# DF7927, RRID:AB_2841339.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CCT A; CCT alpha; CCT-alpha; Choline phosphate cytidylyltransferase A; Choline-phosphate cytidylyltransferase A; CT A; CT; CTP:phosphocholine cytidylyltransferase A; CTPCT; PCY1A_HUMAN; PCYT1; Pcyt1a; Phosphate cytidylyltransferase 1 choline alpha; Phosphate cytidylyltransferase 1 choline alpha isoform; Phosphorylcholine transferase A;

抗原和靶标

免疫原:
Uniprot:

P49585(PCY1A_HUMAN) >>Visit HPA database.

基因/基因ID:
PCYT1A(5130)
序列:
MDAQCSAKVNARKRRKEAPGPNGATEEDGVPSKVQRCAVGLRQPAPFSDEIEVDFSKPYVRVTMEEASRGTPCERPVRVYADGIFDLFHSGHARALMQAKNLFPNTYLIVGVCSDELTHNFKGFTVMNENERYDAVQHCRYVDEVVRNAPWTLTPEFLAEHRIDFVAHDDIPYSSAGSDDVYKHIKEAGMFAPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKKYHLQERVDKVKKKVKDVEEKSKEFVQKVEEKSIDLIQKWEEKSREFIGSFLEMFGPEGALKHMLKEGKGRMLQAISPKQSPSSSPTRERSPSPSFRWPFSGKTSPPCSPANLSRHKAAAYDISEDEED

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Chicken
100
Pig
0
Zebrafish
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P49585 作为底物

Site PTM Type Enzyme
M1 Acetylation
K8 Acetylation
K8 Sumoylation
K8 Ubiquitination
K33 Ubiquitination
K57 Acetylation
K57 Ubiquitination
Y141 Phosphorylation
Y173 Phosphorylation
Y182 Phosphorylation
K183 Ubiquitination
K186 Ubiquitination
T197 Phosphorylation
Y216 Phosphorylation
K228 Ubiquitination
S233 Phosphorylation
K238 Ubiquitination
K261 Ubiquitination
K266 Sumoylation
K270 Ubiquitination
S271 Phosphorylation
K277 Ubiquitination
S315 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1)
S319 Phosphorylation
S321 Phosphorylation
S322 Phosphorylation
S323 Phosphorylation
T325 Phosphorylation
S329 Phosphorylation
S331 Phosphorylation
S333 Phosphorylation
S339 Phosphorylation
T342 Phosphorylation
S343 Phosphorylation
S347 Phosphorylation
S352 Phosphorylation
Y359 Phosphorylation
S362 Phosphorylation

研究背景

功能:

Controls phosphatidylcholine synthesis.

翻译修饰:

The serine residues of the C-terminus are phosphorylated. The inactive soluble form is stabilized by phosphorylation, the active membrane bound form is promoted by anionic lipids or diacylglycerol, and is stabilized by dephosphorylation (By similarity).

Monoubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.

细胞定位:

Cytoplasm>Cytosol. Membrane>Peripheral membrane protein.
Note: It can interconvert between an inactive cytosolic form and an active membrane-bound form.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Homodimer.

蛋白家族:

Belongs to the cytidylyltransferase family.

研究领域

· Human Diseases > Cancers: Overview > Choline metabolism in cancer.   (View pathway)

· Metabolism > Metabolism of other amino acids > Phosphonate and phosphinate metabolism.

· Metabolism > Lipid metabolism > Glycerophospholipid metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

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