SCARF1 Antibody - #DF7922

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产品: SCARF1 抗体
货号: DF7922
描述: Rabbit polyclonal antibody to SCARF1
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse, Rat, Monkey
分子量: 87 kDa; 87kD(Calculated).
蛋白号: Q14162
RRID: AB_2841336

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
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产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat, Monkey
克隆:
Polyclonal
特异性:
SCARF1 Antibody detects endogenous levels of total SCARF1.
RRID:
AB_2841336
引用格式: Affinity Biosciences Cat# DF7922, RRID:AB_2841336.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Acetyl LDL receptor; Endothelial cells scavenger receptor; SCARF1; Scavenger receptor class F member 1; Scavenger receptor expressed by endothelial cells 1; Scavenger receptor expressed by endothelial cells; SREC; SREC-I; SREC_HUMAN;

抗原和靶标

免疫原:
Uniprot:

Q14162(SREC_HUMAN) >>Visit HPA database.

基因/基因ID:
SCARF1(8578)
表达:
Q14162 SREC_HUMAN:

Endothelial cells.

序列:
MGLGLLLPLLLLWTRGTQGSELDPKGQHVCVASSPSAELQCCAGWRQKDQECTIPICEGPDACQKDEVCVKPGLCRCKPGFFGAHCSSRCPGQYWGPDCRESCPCHPHGQCEPATGACQCQADRWGARCEFPCACGPHGRCDPATGVCHCEPGWWSSTCRRPCQCNTAAARCEQATGACVCKPGWWGRRCSFRCNCHGSPCEQDSGRCACRPGWWGPECQQQCECVRGRCSAASGECTCPPGFRGARCELPCPAGSHGVQCAHSCGRCKHNEPCSPDTGSCESCEPGWNGTQCQQPCLPGTFGESCEQQCPHCRHGEACEPDTGHCQRCDPGWLGPRCEDPCPTGTFGEDCGSTCPTCVQGSCDTVTGDCVCSAGYWGPSCNASCPAGFHGNNCSVPCECPEGLCHPVSGSCQPGSGSRDTALIAGSLVPLLLLFLGLACCACCCWAPRSDLKDRPARDGATVSRMKLQVWGTLTSLGSTLPCRSLSSHKLPWVTVSHHDPEVPFNHSFIEPPSAGWATDDSFSSDPESGEADEVPAYCVPPQEGMVPVAQAGSSEASLAAGAFPPPEDASTPFAIPRTSSLARAKRPSVSFAEGTKFAPQSRRSSGELSSPLRKPKRLSRGAQSGPEGREAEESTGPEEAEAPESFPAAASPGDSATGHRRPPLGGRTVAEHVEAIEGSVQESSGPVTTIYMLAGKPRGSEGPVRSVFRHFGSFQKGQAEAKVKRAIPKPPRQALNRKKGSPGLASGSVGQSPNSAPKAGLPGATGPMAVRPEEAVRGLGAGTESSRRAQEPVSGCGSPEQDPQKQAEEERQEEPEYENVVPISRPPEP

研究背景

功能:

Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity).

细胞定位:

Membrane>Single-pass type I membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Endothelial cells.

亚基结构:

Heterophilic interaction with SREC2 via its extracellular domain. The heterophilic interaction is suppressed by the presence of ligand such as Ac-LDL. Interacts with AVIL (By similarity).

文献引用

1). The Role of SREC-Ⅰ in Innate Immunity to Aspergillus fumigatus Keratitis. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2021 (PubMed: 34236384) [IF=5.0]

Application: WB    Species: Human    Sample: HCECs

Figure 1. Expression of SREC-Ⅰ in normal and A fumigatus–treated HCECs and corneas. SREC-Ⅰ mRNA level was significantly higher in A fumigatus–stimulated HCECs at 8 hours comparing with control (A). Immunofluorescence staining for SREC-Ⅰ (green) in normal and A fumigatus–infected human corneas, and quantitative analysis (n = 6/group/time) (t-test). Scale bar = 50 µm. (B) SREC-Ⅰ protein expression level in A fumigatus–stimulated HCECs at 0, 8, 12, 24 and 36 hours (C) and quantitative analysis (D). Values represents means ± SD. *P < 0.05, **P < 0.001 compared with untreated cells by one-way ANOVA test.

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