WARS Antibody - #DF7913

(6)  
产品: WARS 抗体
货号: DF7913
描述: Rabbit polyclonal antibody to WARS
应用: WB IHC IF/ICC
反应: Human, Mouse
预测: Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus
分子量: 25 kDa; 53kD(Calculated).
蛋白号: P23381
RRID: AB_2841329

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 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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实验方案
WB Handbook
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IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
预测:
Zebrafish(92%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Xenopus(100%)
克隆:
Polyclonal
特异性:
WARS Antibody detects endogenous levels of total WARS.
RRID:
AB_2841329
引用格式: Affinity Biosciences Cat# DF7913, RRID:AB_2841329.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Gamma 2; GAMMA-2; Gamma2; hWRS; IFI 53; IFI53; IFP 53; IFP53; Interferon induced protein 53; Interferon-induced protein 53; SYWC_HUMAN; T2-TrpRS; TrpRS; Tryptophan tRNA ligase, cytoplasmic; Tryptophan tRNA ligase 1 cytoplasmic; Tryptophan tRNA ligase; Tryptophan--tRNA ligase; Tryptophanyl tRNA synthetase; Tryptophanyl tRNA synthetase cytoplasmic; WARS; WARS protein; WRS;

抗原和靶标

免疫原:
Uniprot:

P23381(SYWC_HUMAN) >>Visit HPA database.

基因/基因ID:
WARS(7453)
序列:
MPNSEPASLLELFNSIATQGELVRSLKAGNASKDEIDSAVKMLVSLKMSYKAAAGEDYKADCPPGNPAPTSNHGPDATEAEEDFVDPWTVQTSSAKGIDYDKLIVRFGSSKIDKELINRIERATGQRPHHFLRRGIFFSHRDMNQVLDAYENKKPFYLYTGRGPSSEAMHVGHLIPFIFTKWLQDVFNVPLVIQMTDDEKYLWKDLTLDQAYSYAVENAKDIIACGFDINKTFIFSDLDYMGMSSGFYKNVVKIQKHVTFNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFRDRTDIQCLIPCAIDQDPYFRMTRDVAPRIGYPKPALLHSTFFPALQGAQTKMSASDPNSSIFLTDTAKQIKTKVNKHAFSGGRDTIEEHRQFGGNCDVDVSFMYLTFFLEDDDKLEQIRKDYTSGAMLTGELKKALIEVLQPLIAEHQARRKEVTDEIVKEFMTPRKLSFDFQ

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Rabbit
100
Zebrafish
92
Pig
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - P23381 作为底物

Site PTM Type Enzyme
S4 Phosphorylation
K27 Ubiquitination
S32 Phosphorylation
K33 Acetylation
K33 Ubiquitination
S38 Phosphorylation
K41 Ubiquitination
S45 Phosphorylation
K47 Ubiquitination
K51 Ubiquitination
K59 Ubiquitination
K96 Ubiquitination
K102 Ubiquitination
K111 Ubiquitination
K114 Ubiquitination
S139 Phosphorylation
K154 Ubiquitination
K200 Acetylation
K204 Acetylation
K204 Ubiquitination
K220 Ubiquitination
K253 Ubiquitination
K256 Ubiquitination
T259 Phosphorylation
K264 Ubiquitination
S272 Phosphorylation
T301 Phosphorylation
Y316 Phosphorylation
K349 Ubiquitination
S351 Phosphorylation
S353 Phosphorylation
S358 Phosphorylation
K366 Acetylation
K366 Ubiquitination
S378 Phosphorylation
R381 Methylation
T383 Phosphorylation
K431 Acetylation
K431 Ubiquitination
K432 Ubiquitination
K450 Ubiquitination
T453 Phosphorylation
K458 Ubiquitination
K465 Ubiquitination
S467 Phosphorylation

研究背景

功能:

Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas isoform 1 lacks it. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression.

翻译修饰:

Proteolytic cleavage generates 2 forms; T1-TrpRS and T2-TrpRS.

细胞定位:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Homodimer. Isoform 1 and isoform 2 interact with an oxidized form of GAPDH. GAPDH stimulates the aminoacylation activity of isoform 2.

蛋白家族:

Belongs to the class-I aminoacyl-tRNA synthetase family.

研究领域

· Genetic Information Processing > Translation > Aminoacyl-tRNA biosynthesis.

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