产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7874, RRID:AB_2841302.
展开/折叠
Actopaxin; Alpha parvin; Alpha-parvin; Calponin like integrin linked kinase binding protein; Calponin-like integrin-linked kinase-binding protein; CH ILKBP; CH-ILKBP; FLJ10793; FLJ12254; Matrix remodelling associated 2; Matrix remodelling associated protein 2; Matrix-remodeling-associated protein 2; MXRA 2; MXRA2; PARV A; Parva; PARVA_HUMAN;
抗原和靶标
A synthesized peptide derived from human PARVA, corresponding to a region within C-terminal amino acids.
Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver.
- Q9NVD7 PARVA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATSPQKSPSVPKSPTPKSPPSRKKDDSFLGKLGGTLARRKKAKEVSELQEEGMNAINLPLSPIPFELDPEDTMLEENEVRTMVDPNSRSDPKLQELMKVLIDWINDVLVGERIIVKDLAEDLYDGQVLQKLFEKLESEKLNVAEVTQSEIAQKQKLQTVLEKINETLKLPPRSIKWNVDSVHAKSLVAILHLLVALSQYFRAPIRLPDHVSIQVVVVQKREGILQSRQIQEEITGNTEALSGRHERDAFDTLFDHAPDKLNVVKKTLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEGYFVPLHSFFLTPDSFEQKVLNVSFAFELMQDGGLEKPKPRPEDIVNCDLKSTLRVLYNLFTKYRNVE
翻译修饰 - Q9NVD7 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T3 | Phosphorylation | Uniprot | |
| S4 | Phosphorylation | Uniprot | |
| S8 | Phosphorylation | Uniprot | |
| S10 | Phosphorylation | Uniprot | |
| S14 | Phosphorylation | Uniprot | |
| T16 | Phosphorylation | Uniprot | |
| S19 | Phosphorylation | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| S28 | Phosphorylation | Uniprot | |
| K32 | Acetylation | Uniprot | |
| K32 | Ubiquitination | Uniprot | |
| T36 | Phosphorylation | Uniprot | |
| S62 | Phosphorylation | Uniprot | |
| T82 | Phosphorylation | Uniprot | |
| K93 | Ubiquitination | Uniprot | |
| Y124 | Phosphorylation | Uniprot | |
| K131 | Ubiquitination | Uniprot | |
| K135 | Ubiquitination | Uniprot | |
| K140 | Ubiquitination | Uniprot | |
| K154 | Ubiquitination | Uniprot | |
| K156 | Ubiquitination | Uniprot | |
| T167 | Phosphorylation | Uniprot | |
| S174 | Phosphorylation | Uniprot | |
| T252 | Phosphorylation | Uniprot | |
| K260 | Ubiquitination | Uniprot | |
| T284 | Phosphorylation | Uniprot | |
| K343 | Ubiquitination | Uniprot | |
| Y362 | Phosphorylation | Uniprot |
研究背景
Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration.
Cell junction>Focal adhesion. Cell membrane>Peripheral membrane protein>Cytoplasmic side. Cytoplasm>Cytoskeleton. Cytoplasm>Myofibril>Sarcomere>Z line.
Note: Constituent of focal adhesions. Associates with the actin cytoskeleton.
Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver.
Interacts with TGFB1I1 (By similarity). Interacts with ILK, LIMS1 and PXN (via LD motifs). Interacts with ARHGAP31. Interacts with the actin cytoskeleton.
Belongs to the parvin family.
研究领域
· Cellular Processes > Cellular community - eukaryotes > Focal adhesion. (View pathway)
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