NUR77 Antibody - #DF7850

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产品: NUR77 抗体
货号: DF7850
描述: Rabbit polyclonal antibody to NUR77
应用: WB IHC IF/ICC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
蛋白号: P22736
RRID: AB_2841286

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
NUR77 Antibody detects endogenous levels of total NUR77.
RRID:
AB_2841286
引用格式: Affinity Biosciences Cat# DF7850, RRID:AB_2841286.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Early response protein NAK1; GFRP 1; GFRP; GFRP1; Growth factor inducible nuclear protein N10; Growth Factor Inducible Nuclear Protein NP10; Growth Factor Response Protein 1; Hbr1; HMR; Hormone Receptor; MGC9485; N10; N10 nuclear protein; NAK 1; NAK1; Nerve growth factor IB nuclear receptor variant 1; NGFIB; NP 10; NP10; NR4A1; NR4A1_HUMAN; Nuclear hormone receptor NUR/77; Nuclear Hormone Receptor TR3; Nuclear receptor subfamily 4 group A member 1; NUR77; NUR77, mouse, homolog of; Orphan nuclear receptor HMR; Orphan nuclear receptor NR4A1; Orphan nuclear receptor TR3; Orphan receptor tr3; Receptor NGFIB; ST 59; ST-59; ST59; Steroid receptor TR3; Testicular receptor 3; TR 3; TR3; TR3 orphan receptor;

抗原和靶标

免疫原:

A synthesized peptide derived from human NUR77, corresponding to a region within the internal amino acids.

基因/基因ID:
NR4A1(3164)

研究领域

· Environmental Information Processing > Signal transduction > MAPK signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway.   (View pathway)

· Organismal Systems > Endocrine system > Aldosterone synthesis and secretion.

文献引用

1). Natural product mogrol attenuates bleomycin-induced pulmonary fibrosis development through promoting AMPK activation. Journal of Functional Foods, 2021 [IF=3.8]

Application: WB    Species: Mouse    Sample: lung tissues

Fig. 5. . Mogrol attenuated idative oxidative stress and TGF-β1/Smad but upregulated AMPK/Sirt1 signaling pathways in pulmonary fibrosis mice. Pulmonary fibrosis was induced by an intratracheal instillation of bleomycin (BLM). Mice received a gavage of vehicle (0.5% CMC-Na) or mogrol (MG, 1, 5 or 10 mg/kg/d) or nintedanib (NDN, positive drug, 40 mg/kg/d) 7 days after and mice were euthanized on day 22 after bleomycin injection. (a) The protein expression of NOX4 in lung tissues were determined by western blotting. (b) The mRNA levels of NOX4 in lung tissues were determined by PCR analysis. (c and d) Representative images of immunohistochemical analysis of NOX4 expression in the lung section (brown). The protein expression of TGF-β1 (e), Sirt1 (i) and NR4A1 (j) were determined by western blotting. (f) The mRNA levels of TGF-β1 in lung tissues were determined by PCR analysis. The phosphorylation levels of Smad2/3 (g) and AMPK (h) in lung tissues were determined by western blotting. Data are presented as mean ± SD (n = 9).
2). Orphan nuclear receptor NUR77 relieves insulin resistance in HTR-8/SVneo trophoblast cells through activation of autophagy and insulin signaling. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, 2022 (PubMed: 35902547) [IF=3.7]

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