C1QA Antibody - #DF7839

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产品: C1QA 抗体
货号: DF7839
描述: Rabbit polyclonal antibody to C1QA
应用: WB IHC IF/ICC
文献验证: WB, IF/ICC
反应: Human, Mouse
预测: Pig, Bovine, Horse, Sheep, Dog
蛋白号: P02745
RRID: AB_2841278

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
IHC 1:50-1:200, WB 1:1000-3000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse
克隆:
Polyclonal
特异性:
C1QA Antibody detects endogenous levels of total C1QA.
RRID:
AB_2841278
引用格式: Affinity Biosciences Cat# DF7839, RRID:AB_2841278.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

C1qa; C1QA_HUMAN; Complement C1q subcomponent subunit A; Complement component 1 q subcomponent A chain; Complement component 1 q subcomponent alpha polypeptide; Complement component C1q A chain;

抗原和靶标

免疫原:

A synthesized peptide derived from human C1QA, corresponding to a region within the internal amino acids.

基因/基因ID:
C1QA(712)

研究领域

· Human Diseases > Neurodegenerative diseases > Prion diseases.

· Human Diseases > Infectious diseases: Bacterial > Pertussis.

· Human Diseases > Infectious diseases: Parasitic > Chagas disease (American trypanosomiasis).

· Human Diseases > Infectious diseases: Bacterial > Staphylococcus aureus infection.

· Human Diseases > Immune diseases > Systemic lupus erythematosus.

· Organismal Systems > Immune system > Complement and coagulation cascades.   (View pathway)

文献引用

1). PDE4 inhibition alleviates HMGB1/C1q/C3-mediated excessive phagocytic pruning of synapses by microglia and depressive-like behaviors in mice. Brain, behavior, and immunity, 2025 (PubMed: 39947489) [IF=8.8]
2). Physical Exercise Decreases Complement-Mediated Synaptic Loss and Protects Against Cognitive Impairment by Inhibiting Microglial Tmem9-ATP6V0D1 in Alzheimer's Disease. Aging cell, 2025 (PubMed: 39871402) [IF=8.0]
3). Complement C1q-mediated microglial synaptic elimination by enhancing desialylation underlies sevoflurane-induced developmental neurotoxicity. Cell & bioscience, 2024 (PubMed: 38556890) [IF=7.5]

Application: IF/ICC    Species: Mouse    Sample:

Fig. 3 Increased expression of C1q in microglia of mouse hippocampus after neonatal sevoflurane exposures. A Volcano plot showing differentially expressed genes (ǀlog2FCǀ > 1, and FDR 

Application: WB    Species: Mouse    Sample:

Fig. 3 Increased expression of C1q in microglia of mouse hippocampus after neonatal sevoflurane exposures. A Volcano plot showing differentially expressed genes (ǀlog2FCǀ > 1, and FDR 
4). Baicalin ameliorates neuroinflammation by targeting TLR4/MD2 complex on microglia via PI3K/AKT/NF-κB signaling pathway. Neuropharmacology, 2025 (PubMed: 39798687) [IF=4.6]
5). C1QA and COMP: plasma-based biomarkers for early diagnosis of pancreatic neuroendocrine tumors. Scientific reports, 2023 (PubMed: 38030709) [IF=3.8]

Application: WB    Species: Human    Sample:

Figure 5 Validation of potential protein targets. Western blot profiling and densitometric analysis of final selected proteins (A). Densitometric analysis of (B) C1QA (p = 0.001, 0.03, 0.0013); (C) COMP protein (p = 0.011, 0.019), (D) HSP90B1, (E) ITGA2B/CD41, (F) FN1, (G, H) Sandwich ELISA for C1QA binding analysis (I) ROC curve analysis for plasma C1QA levels in Grade I PanNET vs controls (J, K) Sandwich ELISA for COMP analysis (I) ROC curve analysis for plasma COMP levels in Grade I PanNET vs controls.

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