HSD17B1 Antibody - #DF7790

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产品: HSD17B1 抗体
货号: DF7790
描述: Rabbit polyclonal antibody to HSD17B1
应用: WB IHC IF/ICC
反应: Human
分子量: 35 kDa; 35kD(Calculated).
蛋白号: P14061
RRID: AB_2841247

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
克隆:
Polyclonal
特异性:
HSD17B1 Antibody detects endogenous levels of total HSD17B1.
RRID:
AB_2841247
引用格式: Affinity Biosciences Cat# DF7790, RRID:AB_2841247.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

17 beta HSD 1; 17 beta hydroxysteroid dehydrogenase type 1; 17-beta-HSD 1; 17-beta-hydroxysteroid dehydrogenase type 1; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; DHB1_HUMAN; E17KSR; E2DH; EDH17B1; EDH17B2; EDHB17; Estradiol 17 beta dehydrogenase 1; Estradiol 17-beta-dehydrogenase 1; HSD17; HSD17B1; Hydroxysteroid (17 beta) dehydrogenase 1; MGC13814; Placental 17 beta hydroxysteroid dehydrogenase; Placental 17-beta-hydroxysteroid dehydrogenase; SDR28C1; Short chain dehydrogenase/reductase family 28CE,member 1;

抗原和靶标

免疫原:
Uniprot:

P14061(DHB1_HUMAN) >>Visit HPA database.

基因/基因ID:
HSD17B1(3292)
序列:
MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGGGAGPGAEDEAGRGAVGDPELGDPPAAPQ

研究背景

功能:

Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.

细胞定位:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Homodimer.

蛋白家族:

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

研究领域

· Metabolism > Lipid metabolism > Steroid hormone biosynthesis.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Endocrine system > Ovarian steroidogenesis.

文献引用

1). The Curcumin Derivative, H10, Suppresses Hormone-Dependent Prostate Cancer by Inhibiting 17β-Hydroxysteroid Dehydrogenase Type 3. Frontiers in Pharmacology (PubMed: 32457626) [IF=5.6]

Application: WB    Species: mouse    Sample: LC540 (17b-HSD3) cells

FIGURE 3 | Effects of H10 on 17b-HSD3 in LC540 (17b-HSD3) cells. Effects of H10 on the production of (A) T and (B) P. (C) The expression of 17b-HSD3 mRNA.(D) The expression levels of the proteins in the T synthesis pathway were detected by western blotting following treatment with H10. The concentrations of H10 were 0.25, 0.5, and 1 mM, while the concentration of 3858858 (positive control) was 0.25 mM.

Application: IHC    Species: mouse    Sample: tumor

Supplementary Figure 2. |Immunohistochemical examination of 17βHSD3 and AR expression in tumor tissue. (A) Immunohistochemical labeling of 17βHSD3-positive cells. Arrows indicate 17βHSD3 expression.
2). Ormeloxifene, a selective estrogen receptor modulator, protects against pulmonary hypertension. European Journal of Pharmacology (PubMed: 36731722) [IF=5.0]

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