GPRIN1 Antibody - #AF0664

(2)  
产品: GPRIN1 抗体
货号: AF0664
描述: Rabbit polyclonal antibody to GPRIN1
应用: WB IF/ICC
反应: Human
预测: Bovine, Horse, Sheep, Dog
分子量: 102kDa; 102kD(Calculated).
蛋白号: Q7Z2K8
RRID: AB_2834395

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
预测:
Bovine(100%), Horse(82%), Sheep(100%), Dog(91%)
克隆:
Polyclonal
特异性:
GPRIN1 Antibody detects endogenous levels of total GPRIN1.
RRID:
AB_2834395
引用格式: Affinity Biosciences Cat# AF0664, RRID:AB_2834395.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

G protein regulated inducer of neurite outgrowth 1; G protein-regulated inducer of neurite outgrowth 1; GPRIN1; GRIN1; GRIN1_HUMAN; KIAA1893; Z16;

抗原和靶标

免疫原:
Uniprot:

Q7Z2K8(GRIN1_HUMAN) >>Visit HPA database.

基因/基因ID:
GPRIN1(114787)
表达:
Q7Z2K8 GRIN1_HUMAN:

Widely expressed in the central nervous system, with highest levels in spinal cord.

描述:
GRIN1 May be involved in neurite outgrowth. Interacts with activated forms of GNAI1, GNAO1 and GNAZ. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
序列:
MDTAEDPAWLQLLQKDSSPPGPRPTAFFCPQDGSLGAGSSAMRDYCPSQQKASPAPPRHTPDQSPGMESRHRSPSGAGEGASCSDGPRGSLACPSPTCFSPQESPSKETLEAHGASISGTPEATTSGKPEPVSSVKTEPKSSDDRNPMFLEKMDFKSSKQADSTSIGKEDPGSSRKADPMFTGKAEPEILGKGDPVAPGRMDPMTVRKEDLGSLGKVDPLCSSKTYTVSPRKEDPGSLRKVDPVSSDKVDPVFPRKEEPRYSGKEHPVSSEKVAPTSAEKVDLVLSGKRDPGPSGKADPMPLESMDSASTGKTEPGLLGKLIPGSSGKNGPVSSGTGAPGSLGRLDPTCLGMADPASVGNVETVPATKEDSRFLGKMDPASSGEGRPVSGHTDTTASAKTDLTSLKNVDPMSSGKVDPVSLGKMDPMCSGKPELLSPGQAERVSVGKAGTVSPGKEDPVSSRREDPISAGSRKTSSEKVNPESSGKTNPVSSGPGDPRSLGTAGPPSAVKAEPATGGKGDPLSSEKAGLVASGKAAPTASGKAEPLAVGKEDPVSKGKADAGPSGQGDSVSIGKVVSTPGKTVPVPSGKVDPVSLGKAEAIPEGKVGSLPLEKGSPVTTTKADPRASGKAQPQSGGKAETKLPGQEGAAAPGEAGAVCLKKETPQASEKVDPGSCRKAEPLASGKGEPVSLGKADSAPSRKTESPSLGKVVPLSLEKTKPSSSSRQLDRKALGSARSPEGARGSEGRVEPKAEPVSSTEASSLGQKDLEAAGAERSPCPEAAAPPPGPRTRDNFTKAPSWEASAPPPPREDAGTQAGAQACVSVAVSPMSPQDGAGGSAFSFQAAPRAPSPPSRRDAGLQVSLGAAETRSVATGPMTPQAAAPPAFPEVRVRPGSALAAAVAPPEPAEPVRDVSWDEKGMTWEVYGAAMEVEVLGMAIQKHLERQIEEHGRQGAPAPPPAARAGPGRSGSVRTAPPDGAAKRPPGLFRALLQSVRRPRCCSRAGPTAE

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Bovine
100
Sheep
100
Dog
91
Horse
82
Pig
73
Chicken
71
Xenopus
0
Zebrafish
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q7Z2K8 作为底物

Site PTM Type Enzyme
T25 Phosphorylation
Y45 Phosphorylation
S53 Phosphorylation
T60 Phosphorylation
S64 Phosphorylation
S73 Phosphorylation
S75 Phosphorylation
S95 Phosphorylation
T97 Phosphorylation
S104 Phosphorylation
S116 Phosphorylation
T120 Phosphorylation
T182 Phosphorylation
T225 Phosphorylation
Y226 Phosphorylation
S229 Phosphorylation
S237 Phosphorylation
S286 Phosphorylation
T313 Phosphorylation
S334 Phosphorylation
T336 Phosphorylation
S341 Phosphorylation
S389 Phosphorylation
S436 Phosphorylation
S444 Phosphorylation
T450 Phosphorylation
S452 Phosphorylation
S476 Phosphorylation
S491 Phosphorylation
S507 Phosphorylation
T515 Phosphorylation
S540 Phosphorylation
S571 Phosphorylation
S577 Phosphorylation
S608 Phosphorylation
S615 Phosphorylation
T618 Phosphorylation
S634 Phosphorylation
S704 Phosphorylation
S706 Phosphorylation
S714 Phosphorylation
S734 Phosphorylation
S737 Phosphorylation
S744 Phosphorylation
S776 Phosphorylation
S799 Phosphorylation
S850 Phosphorylation
S853 Phosphorylation
S862 Phosphorylation
T873 Phosphorylation
T877 Phosphorylation
S895 Phosphorylation
S914 Phosphorylation
R962 Methylation
R967 Methylation
S968 Phosphorylation
S970 Phosphorylation
T973 Phosphorylation
S993 Phosphorylation

研究背景

功能:

May be involved in neurite outgrowth.

翻译修饰:

Palmitoylation on Cys-999 and/or Cys-1000 is required for membrane targeting.

细胞定位:

Cell membrane>Lipid-anchor. Cell projection>Growth cone.
Note: Highly enriched in growth cone.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Widely expressed in the central nervous system, with highest levels in spinal cord.

亚基结构:

Interacts with activated forms of GNAI1, GNAO1 and GNAZ.

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