| 产品: | CYTH3 抗体 |
| 货号: | DF7653 |
| 描述: | Rabbit polyclonal antibody to CYTH3 |
| 应用: | WB IHC |
| 反应: | Human |
| 预测: | Pig, Bovine, Horse, Dog, Chicken |
| 分子量: | 46 kDa; 46kD(Calculated). |
| 蛋白号: | O43739 |
| RRID: | AB_2841129 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF7653, RRID:AB_2841129.
展开/折叠
CYTH3; ARF nucleotide-binding site opener 3; ARNO3; ARNO3 protein; CYH3_HUMAN; Cyth3; Cytohesin-3; General receptor of phosphoinositides 1; Grp1; PH; PH, SEC7 and coiled-coil domain-containing protein 3; Protein ARNO3; PSCD3; SEC7 and coiled-coil domain-containing protein 3; SEC7 homolog C; Sec7-3; Sec7c;
抗原和靶标
- O43739 CYH3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O43739 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K32 | Ubiquitination | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| K164 | Ubiquitination | Uniprot | |
| K244 | Ubiquitination | Uniprot | |
| K249 | Ubiquitination | Uniprot | |
| K273 | Ubiquitination | Uniprot | |
| Y359 | Phosphorylation | Uniprot | |
| S362 | Phosphorylation | Uniprot | |
| S375 | Phosphorylation | Uniprot | |
| Y386 | Phosphorylation | Uniprot | |
| T391 | Phosphorylation | Uniprot |
研究背景
Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By similarity).
Cytoplasm>Cytosol. Cell membrane>Peripheral membrane protein. Cell junction>Adherens junction. Cell junction>Tight junction.
Note: Translocates from the cytosol to membranes enriched in phosphatidylinositol 3,4,5-trisphosphate.
Almost absent from liver, thymus and peripheral blood lymphocytes.
Interacts with GRASP (By similarity). Interacts with ARF6. Interacts with FRMD4A (By similarity). Interacts with FRMD4B (By similarity).
Binds via its PH domain to the inositol head group of phosphatidylinositol 3,4,5-trisphosphate.
Autoinhibited by its C-terminal basic region.
研究领域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
· Environmental Information Processing > Signal transduction > Phospholipase D signaling pathway. (View pathway)
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