产品: ELOVL1 抗体
货号: AF0670
描述: Rabbit polyclonal antibody to ELOVL1
应用: WB IHC IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 35kDa; 33kD(Calculated).
蛋白号: Q9BW60
RRID: AB_2834387

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Pig(100%), Bovine(89%), Horse(100%), Sheep(89%), Rabbit(100%), Dog(100%)
克隆:
Polyclonal
特异性:
ELOVL1 Antibody detects endogenous levels of total ELOVL1.
RRID:
AB_2834387
引用格式: Affinity Biosciences Cat# AF0670, RRID:AB_2834387.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

3 keto acyl CoA synthase ELOVL1; 3-keto acyl-CoA synthase ELOVL1; CGI 88; Elongation of very long chain fatty acids (FEN1/Elo2 SUR4/Elo3 yeast) like 1; Elongation of very long chain fatty acids like 1; Elongation of very long chain fatty acids protein 1; ELOV1_HUMAN; ELOVL 1; ELOVL FA elongase 1; ELOVL fatty acid elongase 1; ELOVL1; Ssc1; Ssc1, mouse, homolog of; very long chain 3 oxoacyl CoA synthase 1; Very-long-chain 3-oxoacyl-CoA synthase 1;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
表达:
Q9BW60 ELOV1_HUMAN:

Ubiquitous.

描述:
ELOVL1 Could be implicated in tissue-specific synthesis of very long chain fatty acids and sphingolipids. May catalyze one or both of the reduction reaction in fatty acid elongation, i.e., conversion of beta-ketoacyl CoA to beta-hydroxyacyl CoA or reduction of trans-2-enoyl CoA to the saturated acyl CoA derivative. Belongs to the ELO family
序列:
MEAVVNLYQEVMKHADPRIQGYPLMGSPLLMTSILLTYVYFVLSLGPRIMANRKPFQLRGFMIVYNFSLVALSLYIVYEFLMSGWLSTYTWRCDPVDYSNSPEALRMVRVAWLFLFSKFIELMDTVIFILRKKDGQVTFLHVFHHSVLPWSWWWGVKIAPGGMGSFHAMINSSVHVIMYLYYGLSAFGPVAQPYLWWKKHMTAIQLIQFVLVSLHISQYYFMSSCNYQYPVIIHLIWMYGTIFFMLFSNFWYHSYTKGKRLPRALQQNGAPGIAKVKAN

种属预测

种属预测:

score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Dog
100
Rabbit
100
Bovine
89
Sheep
89
Chicken
67
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q9BW60 作为底物

Site PTM Type Enzyme
M1 Acetylation
K54 Ubiquitination
K275 Ubiquitination

研究背景

功能:

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.

细胞定位:

Endoplasmic reticulum membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Ubiquitous.

亚基结构:

Interacts with LASS2, TECR and HSD17B12.

蛋白家族:

The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

Belongs to the ELO family. ELOVL1 subfamily.

研究领域

· Metabolism > Lipid metabolism > Fatty acid elongation.

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