Aggrecan Antibody - #DF7561

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产品: Aggrecan 抗体
货号: DF7561
描述: Rabbit polyclonal antibody to Aggrecan
应用: WB IHC IF/ICC
文献验证: WB, IHC, IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Sheep, Rabbit, Dog
蛋白ID: P16112
RRID: AB_2841055

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 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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#DF7561-BP

Aggrecan Peptide
相关下载
抗原肽/阻断肽MS报告
抗原肽/阻断肽HPLC报告
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
Aggrecan Antibody detects endogenous levels of total Aggrecan.
RRID:
AB_2841055
引用格式: Affinity Biosciences Cat# DF7561, RRID:AB_2841055.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

ACAN; AGC 1; AGC1; AGCAN; Aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122); Aggrecan 1; Aggrecan core protein; Aggrecan proteoglycan; Aggrecan structural proteoglycan of cartilage; Aggrecan1; ATEGQV; Cartilage specific proteoglycan core protein; Chondroitin sulfate proteoglycan 1; Chondroitin sulfate proteoglycan 1 large aggregating proteoglycan antigen identified by monoclonal antibody A0122; Chondroitin sulfate proteoglycan core protein 1; CSPG 1; CSPG1; CSPGCP; JSCATE; Large aggregating proteoglycan; mcspg; mgsk16; MSK 16; MSK16; SEDK;

抗原和靶标

免疫原:

A synthesized peptide derived from human Aggrecan, corresponding to a region within N-terminal amino acids.

基因/基因ID:
ACAN(176)

文献引用

1). Hydrogen Ion Capturing Hydrogel Microspheres for Reversing Inflammaging. Advanced materials (Deerfield Beach, Fla.), 2024 (PubMed: 37699155) [IF=27.4]
2). An anti-inflammatory and neuroprotective biomimetic nanoplatform for repairing spinal cord injury. Bioactive Materials, 2022 (PubMed: 35845318) [IF=18.9]
3). Cartilage-Penetrating Framework Nucleic Acid Nanoparticles Ameliorate Osteoarthritis by Promoting Drug Delivery and Chondrocyte Uptake. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025 (PubMed: 40192172) [IF=15.1]
4). CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress-Induced Ferroptosis through the miR-548I-IL17A Axis. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026 (PubMed: 41514293) [IF=15.1]
5). Glycolysis-Derived Lactate Induces ACSL4 Expression and Lactylation to Activate Ferroptosis during Intervertebral Disc Degeneration. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025 (PubMed: 40171826) [IF=15.1]
6). Bioactive Patch for Rotator Cuff Repairing via Enhancing Tendon-to-Bone Healing: A Large Animal Study and Short-Term Outcome of a Clinical Trial. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024 (PubMed: 38922803) [IF=15.1]

Application: IF/ICC    Species: human    Sample: BMSCs

Figure 6 Chondrogenic evaluation of UC extracts. A–C) Immunofluorescence staining for Aggrecan, SOX9 and COL-II in BMSCs under different induction conditions. D,E) Positive rate and mean fluorescence intensity of Immunofluorescence. F,G) Western-blot of Aggrecan, SOX9 and COL-II in BMSCs under different induction conditions. H) Chondrogenic pellet evaluation by staining under different induction conditions. I) Positive rate of immunohistochemistry of pellet staining. The results are presented as means ± SD. (*P < 0.05 compared with control.).

Application: WB    Species: human    Sample: BMSCs

Figure 6 Chondrogenic evaluation of UC extracts. A–C) Immunofluorescence staining for Aggrecan, SOX9 and COL-II in BMSCs under different induction conditions. D,E) Positive rate and mean fluorescence intensity of Immunofluorescence. F,G) Western-blot of Aggrecan, SOX9 and COL-II in BMSCs under different induction conditions. H) Chondrogenic pellet evaluation by staining under different induction conditions. I) Positive rate of immunohistochemistry of pellet staining. The results are presented as means ± SD. (*P < 0.05 compared with control.).
7). A high-resolution route map reveals distinct stages of chondrocyte dedifferentiation for cartilage regeneration. Bone research, 2022 (PubMed: 35477573) [IF=14.3]
8). Sustained therapeutic effects of self-assembled hyaluronic acid nanoparticles loaded with α-Ketoglutarate in various osteoarthritis stages. Biomaterials, 2024 (PubMed: 39326362) [IF=12.8]

Application: IHC    Species: Mouse    Sample:

Fig. 9. αKG protects articular cartilage by modulating cartilage matrix homeostasis. Immunohistochemistry staining of Col2a1, Acan, MMP13, and Adamts4 in the knee joint cartilage of advanced OA mice under different treatments.
9). Melatonin attenuates oxidative stress-induced ferroptosis of nucleus pulposus cells and intervertebral disc degeneration via PI3K/AKT-mTOR pathway. International journal of surgery (London, England), 2026 (PubMed: 41729690) [IF=12.5]
10). Cell Shock Absorption via Stress Relaxation Hydrogel Microspheres for Alleviating Endoplasmic Reticulum Stress in Chondrocytes. Research (Washington, D.C.), 2025 (PubMed: 40678150) [IF=11.0]

Application: IF/ICC    Species: Rat    Sample:

Fig. 4. Stressed-relaxed HAMA@Lip exhibits good biocompatibility and alleviates chondrocyte ERS and OA phenotypes. (A) CCK-8 assay results for chondrocytes treated with blank, Lip, stress-relaxed HAMA, and stress-relaxed HAMA@Lip on days 1, 2, and 3 (Blank, Lipo-Wyrgrl@TUDCA; Stress-relaxed HAMA; Stress-relaxed HAMA@Lipo). (B) Cell growth curves under different concentrations of tunicamycin. (C and D) ThT staining results and corresponding fluorescence quantification for different treatment groups (n = 3). (E and F) Col II staining results and corresponding fluorescence quantification for different treatment groups (n = 3). (G and H) Aggrecan staining results and corresponding fluorescence quantification for different treatment groups (n = 3). (I and J) MMP13 staining results and corresponding fluorescence quantification for different treatment groups (n = 3). One-way ANOVA with Tukey’s post hoc test. ns: no significance, *P < 0.05, **P < 0.01.
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