ASC2 Antibody - #DF7540

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产品: ASC2 抗体
货号: DF7540
描述: Rabbit polyclonal antibody to ASC2
应用: WB IHC
文献验证: WB
反应: Human, Mouse, Rat
蛋白号: Q8WXC3
RRID: AB_2841039

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
ASC2 Antibody detects endogenous levels of total ASC2.
RRID:
AB_2841039
引用格式: Affinity Biosciences Cat# DF7540, RRID:AB_2841039.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

PAAD domain only protein; PAAD-only protein 1; POP1; PYC1; PYD (pyrin domain) containing 1; PYDC1; PYDC1_HUMAN; Pyrin domain containing 1; Pyrin domain-containing protein 1; Pyrin only protein 1; Pyrin-only protein 1;

抗原和靶标

免疫原:

A synthesized peptide derived from human ASC2, corresponding to a region within N-terminal amino acids.

基因/基因ID:
PYDC1(260434)

研究领域

· Organismal Systems > Immune system > NOD-like receptor signaling pathway.   (View pathway)

文献引用

1). Integrated metabolomics and network pharmacology to explore the mechanism of Huzhang Erjin Decoction against ANIT-induced cholestatic hepatitis. Journal of ethnopharmacology, 2025 (PubMed: 40466881) [IF=4.8]

Application: WB    Species: Mouse    Sample:

Fig. 6. Mechanism validation results of HED in the treatment of cholestatic hepatitis. (A–G) Protein expression of PPARγ, NLRP3, pro caspase-1, IL-1β, and ASC was detected by Western blotting (n = 3). Compared with the control group, ∗P < 0.05, ∗∗P < 0.01. Compared with the model group, #P < 0.05, ##P < 0.01.
2). lncRNA‑MALAT1 promotes high glucose‑induced H9C2 cardiomyocyte pyroptosis by downregulating miR‑141‑3p expression. Molecular Medicine Reports, 2021 (PubMed: 33576445) [IF=3.4]

Application: WB    Species: Human    Sample: H9C2 cells

Figure 3. Effects of MALAT1 on pyroptosis-associated protein expression levels. ASC, GSDMD-N, caspase-1, NLRP3 and GSDMD protein expression levels were measured via western blotting. *P<0.05 and **P<0.01 vs. NG; #P<0.05 and ##P<0.01 vs. HG; ^P<0.05 and ^^P<0.01 vs. NC1; %P<0.05 vs. NC2. MALAT1, metastasis-associated lung adenocarcinoma transcript-1; ASC, apoptosis-associated speck-like protein; GSDMD, gasdermin D; NLRP3, nucleotide oligomerization domain-like receptor protein 3; NG, normal glucose; HG, high glucose; NC, negative control; NC1, MALAT1 overexpression NC group; NC2, MALAT1 knockdown NC group; si, small interfering RNA.

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