GLUT2 Antibody - #DF7510

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产品: GLUT2 抗体
货号: DF7510
描述: Rabbit polyclonal antibody to GLUT2
应用: WB IHC
文献验证: WB
反应: Human, Mouse, Rat
蛋白ID: P11168
RRID: AB_2841009

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GLUT2 Peptide
相关下载
抗原肽/阻断肽MS报告
抗原肽/阻断肽HPLC报告
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
GLUT2 Antibody detects endogenous levels of total GLUT2.
RRID:
AB_2841009
引用格式: Affinity Biosciences Cat# DF7510, RRID:AB_2841009.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

liver; Glucose Transporter 2; Glucose Transporter GLUT2; Glucose transporter type 2; Glucose transporter type 2 liver; Glucose transporter, liver/islet; GLUT-2; GLUT2; GTR2_HUMAN; GTT2; SLC2A2; Solute carrier family 2 (facilitated glucose transporter) member 2; Solute carrier family 2 facilitated glucose transporter member 2; Solute carrier family 2, facilitated glucose transporter member 2;

抗原和靶标

免疫原:

A synthesized peptide derived from human GLUT2, corresponding to a region within N-terminal amino acids.

基因/基因ID:
SLC2A2(6514)

研究领域

· Human Diseases > Endocrine and metabolic diseases > Type II diabetes mellitus.

· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.

· Human Diseases > Endocrine and metabolic diseases > Maturity onset diabetes of the young.

· Human Diseases > Cancers: Overview > Central carbon metabolism in cancer.   (View pathway)

· Organismal Systems > Endocrine system > Insulin secretion.   (View pathway)

· Organismal Systems > Endocrine system > Prolactin signaling pathway.   (View pathway)

· Organismal Systems > Endocrine system > Glucagon signaling pathway.

· Organismal Systems > Digestive system > Carbohydrate digestion and absorption.

文献引用

1). Recurrent moderate hypoglycemia accelerates the progression of cognitive deficits through impairment of TRPC6/GLUT3 pathway in diabetic APP/PS1 mice. JCI Insight, 2022 (PubMed: 35077394) [IF=8.0]

Application: WB    Species: Mice    Sample: hippocampal homogenates

Figure 5 RH reduced brain GLUT3-mediated glucose uptake in STZ-induced APP/PS1-DM mice. (A) Representative PET/CT images showing in vivo brain 18F-FDG uptake (coronal, sagittal, and transaxial sections, n = 6 mice for each group). Cor, Cortex; Hip, hippocampus; Mid, midbrain; HPOA, hypothalamus; BS, brain stem; Cer, cerebellum; OB, Olfactory Bulb; BF, basal forebrain; Tha, thalamus; SC, superior colliculi; CG, central gray; Str, striatum. (B) Quantification for SUV of 18F-FDG in brain region (n = 6 for mice for each group). (C) Western blot and quantitation for GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, SGLT1, and SGLT2 in hippocampal homogenates (n = 3 mice for each group). The data are expressed as the mean ± SEM. Statistical significance was assessed using unpaired Student’s t test. *P < 0.05 and **P < 0.01, APP/PS1-DM versus APP/PS1; #P < 0.05 and ##P < 0.01, APP/PS1-DM-RH versus APP/PS1-DM; WT versus APP/PS1; NS, no significant difference.
2). Liubao brick tea activates the PI3K-Akt signaling pathway to lower blood glucose, metabolic disorders and insulin resistance via altering the intestinal flora. FOOD RESEARCH INTERNATIONAL, 2021 (PubMed: 34507739) [IF=7.0]

Application: WB    Species: Mice    Sample: liver tissue

Fig. 7. LBT treatment activated the PI3K/Akt pathway in the liver of hyperglycemic and insulin-resistant mice and insulin-resistant HepG2 cells. (A) Hepatic immunohistochemical analysis of PI3K p85, pAkt and Akt protein expressions, (B) Cellular western blotting analysis of GLUT2, PI3K p85 and Akt protein expressions. Different letters represent a significant difference among multiple groups, * represents a significance compared with the Control group, # represents a significance between two groups, ns represents no significance. #,*, p < 0.05; ##, **, p < 0.01.
3). NLRP3 inflammasome blocked the glycolytic pathway via targeting to PKLR in arsenic-induced hepatic insulin resistance. Ecotoxicology and environmental safety, 2021 (PubMed: 34364127) [IF=6.2]

Application: WB    Species: Rat    Sample: livers

Fig. 3. NaAsO2 inhibited the glycolytic pathway. (A) The proteins of glycolytic pathway in rat livers were analyzed by Western blot. (B–E) The relative expression of PKLR, GCK, LDHB and GLUT2 was shown as the percentage of β-actin. (F) The effect of NaAsO2 on the release of lactate in rat liver. Results were means ± SEM, and n = 3. **P 
4). Hydroxytyrosol Prevents Metabolic-Associated Steatohepatitis by Inhibiting SOCS2-Mediated Ferroptosis in High-Fat Diet Mice. Journal of agricultural and food chemistry, 2026 (PubMed: 41674361) [IF=5.7]
5). Elevated lactate aggravates insulin resistance by downregulating the PI3K/AKT/GLUT2 pathway in type 2 diabetes mellitus. Life sciences, 2026 (PubMed: 41932385) [IF=5.2]
6). Involvement of disulfidptosis in the pathophysiology of autism spectrum disorder. Life sciences, 2025 (PubMed: 40054734) [IF=5.2]
7). Hydroxytyrosol improved insulin resistance in male offspring born to high-fat diet dams by remodeling gut microbiota. The Journal of nutritional biochemistry, 2025 (PubMed: 40716617) [IF=4.8]
8). Network pharmacology-based elucidation of bioactive compounds and experimental exploration of antidiabetic mechanisms of Hydrolea zeylanica. Cellular signalling, 2024 (PubMed: 38052370) [IF=4.4]
9). Nrf2/Bach1 axis regulates redox homeostasis and energy metabolism to optimize Sertoli cell-mediated efferocytosis. Molecular and cellular endocrinology, 2025 (PubMed: 40975426) [IF=3.8]
10). The protective role of the MKP-5-JNK/P38 pathway in glucolipotoxicity-induced islet β-cell dysfunction and apoptosis. EXPERIMENTAL CELL RESEARCH, 2019 (PubMed: 31202710) [IF=3.3]

Application: WB    Species: mouse    Sample: MIN6-PC and MIN6-MKP5 cells

Fig. 3. |Cell dysfunction caused by GP is improved in MKP-5 overexpressing MIN6 cells. (B, C) MIN6-PC and MIN6-MKP5 cells were stimulated with GP for 24 h. The phosphorylation of AKT and the expression of GLUT-2 were assessed by western blotting (B). Relative levels of PDX-1 and GCK mRNA were quantified by real-time PCR analysis (C). Data are given as means ± SEM. *, P < 0.05.
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