| 产品: | CDC7 抗体 |
| 货号: | DF3005 |
| 描述: | Rabbit polyclonal antibody to CDC7 |
| 应用: | WB IF/ICC |
| 反应: | Human, Mouse |
| 预测: | Pig, Bovine, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 70 KD; 64kD(Calculated). |
| 蛋白号: | O00311 |
| RRID: | AB_2840984 |
产品描述
*The optimal dilutions should be determined by the end user.
*Tips:
WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.
引用格式: Affinity Biosciences Cat# DF3005, RRID:AB_2840984.
展开/折叠
Cdc 7; CDC7; CDC7 cell division cycle 7; CDC7 cell division cycle 7 like 1; CDC7 L1; Cdc7 like 1; CDC7 related kinase; CDC7-related kinase; CDC7_HUMAN; CDC7L 1; CDC7L1; Cell division cycle 7 homolog; Cell division cycle 7 kinase; Cell division cycle 7 like protein 1; Cell division cycle 7 related protein kinase; Cell division cycle 7-related protein kinase; HsCDC 7; HsCdc7; Hsk 1; Hsk1; HuCDC 7; huCdc7; MGC117361; MGC126237; MGC126238;
抗原和靶标
- O00311 CDC7_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
种属预测
score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。
High(score>80) Medium(80>score>50) Low(score<50) No confidence
翻译修饰 - O00311 作为底物
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S16 | Phosphorylation | Uniprot | |
| S27 | Phosphorylation | Uniprot | |
| K29 | Ubiquitination | Uniprot | |
| K30 | Ubiquitination | Uniprot | |
| K36 | Sumoylation | Uniprot | |
| K36 | Ubiquitination | Uniprot | |
| K59 | Sumoylation | Uniprot | |
| K59 | Ubiquitination | Uniprot | |
| K90 | Ubiquitination | Uniprot | |
| K179 | Sumoylation | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| S181 | Phosphorylation | Uniprot | |
| K191 | Ubiquitination | Uniprot | |
| K207 | Ubiquitination | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| S216 | Phosphorylation | Uniprot | |
| K227 | Ubiquitination | Uniprot | |
| K235 | Sumoylation | Uniprot | |
| K235 | Ubiquitination | Uniprot | |
| S239 | Phosphorylation | Uniprot | |
| K244 | Sumoylation | Uniprot | |
| K244 | Ubiquitination | Uniprot | |
| K253 | Ubiquitination | Uniprot | |
| S255 | Phosphorylation | Uniprot | |
| K257 | Ubiquitination | Uniprot | |
| K268 | Sumoylation | Uniprot | |
| K268 | Ubiquitination | Uniprot | |
| K274 | Sumoylation | Uniprot | |
| K274 | Ubiquitination | Uniprot | |
| S277 | Phosphorylation | Uniprot | |
| S285 | Phosphorylation | Uniprot | |
| S296 | Phosphorylation | Uniprot | |
| S297 | Phosphorylation | Uniprot | |
| S302 | Phosphorylation | Uniprot | |
| K306 | Ubiquitination | Uniprot | |
| K312 | Ubiquitination | Uniprot | |
| S318 | Phosphorylation | Uniprot | |
| K331 | Acetylation | Uniprot | |
| K331 | Sumoylation | Uniprot | |
| K331 | Ubiquitination | Uniprot | |
| K340 | Ubiquitination | Uniprot | |
| K358 | Ubiquitination | Uniprot | |
| T376 | Phosphorylation | P06493 (CDK1) , P24941 (CDK2) | Uniprot |
| T386 | Phosphorylation | Uniprot | |
| Y415 | Phosphorylation | Uniprot | |
| K441 | Ubiquitination | Uniprot | |
| K445 | Ubiquitination | Uniprot | |
| K451 | Acetylation | Uniprot | |
| K451 | Ubiquitination | Uniprot | |
| T472 | Phosphorylation | Uniprot | |
| K474 | Ubiquitination | Uniprot | |
| S484 | Phosphorylation | Uniprot | |
| S490 | Phosphorylation | Uniprot | |
| K492 | Ubiquitination | Uniprot | |
| S498 | Phosphorylation | Uniprot | |
| T503 | Phosphorylation | Uniprot | |
| S509 | Phosphorylation | Uniprot | |
| S512 | Phosphorylation | Uniprot | |
| S556 | Phosphorylation | Uniprot | |
| T559 | Phosphorylation | Uniprot | |
| K570 | Ubiquitination | Uniprot | |
| S573 | Phosphorylation | Uniprot |
翻译修饰 - O00311 作为激酶
| Substrate | Site | Source |
|---|---|---|
| O75475 (PSIP1) | S206 | Uniprot |
| P49736 (MCM2) | S4 | Uniprot |
| P49736 (MCM2) | S5 | Uniprot |
| P49736 (MCM2) | S7 | Uniprot |
| P49736 (MCM2) | S13 | Uniprot |
| P49736 (MCM2) | S27 | Uniprot |
| P49736 (MCM2) | S31 | Uniprot |
| P49736 (MCM2) | S40 | Uniprot |
| P49736 (MCM2) | S41 | Uniprot |
| P49736 (MCM2) | S53 | Uniprot |
| P49736 (MCM2) | S108 | Uniprot |
| P49736 (MCM2) | S139 | Uniprot |
| P49736 (MCM2) | S220 | Uniprot |
| Q9HAW4 (CLSPN) | S67 | Uniprot |
| Q9HAW4 (CLSPN) | S110 | Uniprot |
| Q9HAW4 (CLSPN) | S260 | Uniprot |
| Q9HAW4 (CLSPN) | S265 | Uniprot |
| Q9HAW4 (CLSPN) | S704 | Uniprot |
| Q9HAW4 (CLSPN) | S721 | Uniprot |
| Q9HAW4 (CLSPN) | S744 | Uniprot |
| Q9HAW4 (CLSPN) | S1129 | Uniprot |
| Q9HAW4 (CLSPN) | S1147 | Uniprot |
| Q9NS91 (RAD18) | S434 | Uniprot |
研究背景
Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.
Nucleus.
Forms a complex with either DBF4/DBF4A or DBF4B, leading to the activation of the kinase activity.
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.
研究领域
· Cellular Processes > Cell growth and death > Cell cycle. (View pathway)
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