PDLIM1 Antibody - #DF3003

Figure 2 IA tissue proteome remodeling due to IA formation and rupture Five pairs of IA and STA tissues surgically excised from intracranial aneurysm patients. Differentially expressed proteins between IA group and STA group, as determined by plotting Student’s t‐test (P‐value < 0.05, two‐sided) P‐values versus the log2 fold change (IA/STA) are represented on volcano plots. Proteins with significant change in expression levels are indicated by pink (upregulated) and blue (downregulated) dots. The dashed line (x = ±1) represents the cutoff of the log2 fold change in protein levels, and dashed line (y = 2) represents the cutoff of the −log10 t‐test P‐value. Significantly altered top ranked pathways in IA tissues compared with STA tissues. Interaction network of tissue downregulated proteins in IA group compared to STA group. Western blot validation of selected protein (PDLIM1) differentially expressed between STA and IA. Downregulation of PDLIM1 in IA tissue as compared to STA tissue was confirmed. Immunoblots showing expression differences of PDLIM1 in STA and IA specimens are shown in the left panel using β‐tubulin as the loading control. The semi‐quantitative densitometric measurement of blot bands is summarized in the lower panel. Error bars indicate standard deviations (three biological replicates for each group, two‐tailed Student’s t‐test, * P‐value < 0.05).