PD1 Antibody - #DF2943

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产品: PD1 抗体
货号: DF2943
描述: Rabbit polyclonal antibody to PD1
应用: WB
文献验证:
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Rabbit, Dog
蛋白号: Q15116
RRID: AB_2840927

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
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说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
PD1 Antibody detects endogenous levels of total PD1.
RRID:
AB_2840927
引用格式: Affinity Biosciences Cat# DF2943, RRID:AB_2840927.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CD279; CD279 antigen; hPD 1; hPD l; hPD-1; hSLE1; PD 1; PD-1; PD1; PDCD 1; PDCD1; PDCD1_HUMAN; Programmed cell death 1; Programmed cell death 1 protein; Programmed cell death protein 1; Protein PD 1; Protein PD-1; SLEB2; Systemic lupus erythematosus susceptibility 2;

抗原和靶标

免疫原:

A synthesized peptide derived from human PD1, corresponding to a region within the internal amino acids.

基因/基因ID:
PDCD1(5133)

研究领域

· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs).   (View pathway)

· Organismal Systems > Immune system > T cell receptor signaling pathway.   (View pathway)

文献引用

1). PD-1 inhibitor induces myocarditis by reducing regulatory T cells, activating inflammatory responses, promoting myocardial apoptosis and autophagy. CYTOKINE, 2022 (PubMed: 35691121) [IF=3.7]
2). PD-1-Positive Tumor-Associated Macrophages Define Poor Clinical Outcomes in Patients With Muscle Invasive Bladder Cancer Through Potential CD68/PD-1 Complex Interactions. Frontiers in Oncology, 2021 (PubMed: 34079767) [IF=3.5]

Application: IHC    Species: Human    Sample: TAMs

FIGURE 3 | (A) Immunohistochemical staining of PD-1-positive TAMs (red arrow), PD-1-negative TAMs (purple arrow), strong PD-L1 and weak PD-L1 expression. (B) Kaplan-Meier analysis of OS in patients with MIBC with PD-1-positive TAMs in the Shanghai General Hospital cohort. (C) Kaplan-Meier analysis of DFS in patients with MIBC with PD-1-positive TAMs in the Shanghai General Hospital cohort. (D) PD-1-positive TAMs showed less CD8-postive T cells nearby. ***p < 0.001 (Student’s t-test). (E) The number of PD-1-positive TAMs showed a correlation with PD-L1 expression in the Shanghai General Hospital cohort.

Application: IF/ICC    Species: Human    Sample: TAMs

FIGURE 4 | (A) Immunofluorescence staining confirmation for the appearance of PD-1-positive TAMs. (B) mRNA expression of CD68 showed a correlation with PD-1 expression in the TCGA cohort. (C) mRNA expression of CD68 showed a correlation with PD-L1 expression in the TCGA cohort.
3). SIRT7 Is a Prognostic Biomarker Associated With Immune Infiltration in Luminal Breast Cancer. Frontiers in Oncology, 2020 (PubMed: 32528869) [IF=3.5]

Application: IHC    Species: human    Sample: breast cancer

FIGURE 5 | Correlation between sirtuin (SIRT)7 expression and immune infiltration levels of M1 macrophages and T cell exhaustion in breast cancer-luminal.. (B) Tumor infiltration of M1 macrophages and T cell exhaustion in breast cancer-luminal. The expression of SIRT7 (a: + + +, d: +). The expression of IRF5 (b: ++, e: –). The expression of PD1 (PDCD1) (c: + + +, f: +). The expression density of SIRT7, PD1, and IRF5 in breast cancer tissue was quantitated by scoring staining intensity,including negative (–) and weak (+) staining, moderate (++) and strong (+ + +) staining, respectively

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