STA13 Antibody - #AF0732

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产品: STA13 抗体
货号: AF0732
描述: Rabbit polyclonal antibody to STA13
应用: WB IHC IF/ICC
反应: Human, Mouse
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus
分子量: 125kDa; 125kD(Calculated).
蛋白号: Q9Y3M8
RRID: AB_2834356

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WB Handbook
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IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
预测:
Pig(100%), Bovine(100%), Horse(91%), Sheep(100%), Rabbit(91%), Dog(100%), Xenopus(82%)
克隆:
Polyclonal
特异性:
STA13 Antibody detects endogenous levels of total STA13.
RRID:
AB_2834356
引用格式: Affinity Biosciences Cat# AF0732, RRID:AB_2834356.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

46H23.2; ARHGAP37; Deleted in liver cancer 2 protein; Deleted in liver cancer protein 2; DLC-2; DLC2; GT650; Rho GTPase activating protein on chromosome 13q12; Rho GTPase-activating protein; STA13; STA13_HUMAN; StAR related lipid transfer (START) domain containing 13; StAR-related lipid transfer protein 13; StARD13; START domain-containing protein 13;

抗原和靶标

免疫原:
Uniprot:

Q9Y3M8(STA13_HUMAN) >>Visit HPA database.

基因/基因ID:
STARD13(90627)
表达:
Q9Y3M8 STA13_HUMAN:

Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines.

描述:
StARD13 GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. Homodimer. Interacts with TAX1BP1. 5 isoforms of the human protein are produced by alternative splicing.
序列:
MFSQVPRTPASGCYYLNSMTPEGQEMYLRFDQTTRRSPYRMSRILARHQLVTKIQQEIEAKEACDWLRAAGFPQYAQLYEDSQFPINIVAVKNDHDFLEKDLVEPLCRRLNTLNKCASMKLDVNFQRKKGDDSDEEDLCISNKWTFQRTSRRWSRVDDLYTLLPRGDRNGSPGGTGMRNTTSSESVLTDLSEPEVCSIHSESSGGSDSRSQPGQCCTDNPVMLDAPLVSSSLPQPPRDVLNHPFHPKNEKPTRARAKSFLKRMETLRGKGAHGRHKGSGRTGGLVISGPMLQQEPESFKAMQCIQIPNGDLQNSPPPACRKGLPCSGKSSGESSPSEHSSSGVSTPCLKERKCHEANKRGGMYLEDLDVLAGTALPDAGDQSRMHEFHSQENLVVHIPKDHKPGTFPKALSIESLSPTDSSNGVNWRTGSISLGREQVPGAREPRLMASCHRASRVSIYDNVPGSHLYASTGDLLDLEKDDLFPHLDDILQHVNGLQEVVDDWSKDVLPELQTHDTLVGEPGLSTFPSPNQITLDFEGNSVSEGRTTPSDVERDVTSLNESEPPGVRDRRDSGVGASLTRPNRRLRWNSFQLSHQPRPAPASPHISSQTASQLSLLQRFSLLRLTAIMEKHSMSNKHGWTWSVPKFMKRMKVPDYKDKAVFGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPENVNYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQYVSKEQRLQAVQAAILLLADENREVLQTLLCFLNDVVNLVEENQMTPMNLAVCLAPSLFHLNLLKKESSPRVIQKKYATGKPDQKDLNENLAAAQGLAHMIMECDRLFEVPHELVAQSRNSYVEAEIHVPTLEELGTQLEESGATFHTYLNHLIQGLQKEAKEKFKGWVTCSSTDNTDLAFKKVGDGNPLKLWKASVEVEAPPSVVLNRVLRERHLWDEDFVQWKVVETLDRQTEIYQYVLNSMAPHPSRDFVVLRTWKTDLPKGMCTLVSLSVEHEEAQLLGGVRAVVMDSQYLIEPCGSGKSRLTHICRIDLKGHSPEWYSKGFGHLCAAEVARIRNSFQPLIAEGPETKI

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Bovine
100
Sheep
100
Dog
100
Horse
91
Rabbit
91
Xenopus
82
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q9Y3M8 作为底物

Site PTM Type Enzyme
M1 Acetylation
S3 Phosphorylation
S37 Phosphorylation
Y39 Phosphorylation
S42 Phosphorylation
K100 Ubiquitination
S118 Phosphorylation
S133 Phosphorylation
S141 Phosphorylation
S154 Phosphorylation
Y160 Phosphorylation
T161 Phosphorylation
S171 Phosphorylation
K247 Ubiquitination
R267 Methylation
S314 Phosphorylation
S334 Phosphorylation
T345 Phosphorylation
S389 Phosphorylation
S411 Phosphorylation
S414 Phosphorylation
S416 Phosphorylation
S430 Phosphorylation
S454 Phosphorylation
S457 Phosphorylation
Y459 Phosphorylation
Y468 Phosphorylation
S470 Phosphorylation
T547 Phosphorylation
S572 Phosphorylation
S577 Phosphorylation
S589 Phosphorylation
S828 Phosphorylation
S829 Phosphorylation
T930 Phosphorylation
K942 Ubiquitination

研究背景

功能:

GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.

细胞定位:

Cytoplasm. Membrane>Peripheral membrane protein>Cytoplasmic side. Mitochondrion membrane>Peripheral membrane protein>Cytoplasmic side. Lipid droplet.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines.

亚基结构:

Homodimer. Interacts with TAX1BP1.

文献引用

1). Phillygenin inhibited M1 macrophage polarization and reduced hepatic stellate cell activation by inhibiting macrophage exosomal miR-125b-5p. BIOMEDICINE & PHARMACOTHERAPY, 2023 (PubMed: 36652738) [IF=7.5]

Application: WB    Species: Mouse    Sample: mHSCs

Fig. 5. PHI inhibited HSC activation through macrophage exosomal miR-125b-5p targeting Stard13. (a) The expression of miR-125b-5p, miR-21a-5p, miR-199a-5p, miR-29b-3p and miR-223–3p in RAW264.7 cells after treatment with LPS/IFNγ and PHI for 12 h was detected by RT-qPCR (n = 3). ###P 

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