ZNF148 Antibody - #AF0792

(3)  
产品: ZNF148 抗体
货号: AF0792
描述: Rabbit polyclonal antibody to ZNF148
应用: WB IHC IF/ICC
反应: Human, Mouse, Rat
预测: Zebrafish, Bovine, Horse, Sheep, Dog, Xenopus
分子量: 89kDa; 89kD(Calculated).
蛋白号: Q9UQR1
RRID: AB_2834348

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说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
预测:
Zebrafish(100%), Bovine(100%), Horse(100%), Sheep(100%), Dog(100%), Xenopus(80%)
克隆:
Polyclonal
特异性:
ZNF148 Antibody detects endogenous levels of total ZNF148.
RRID:
AB_2834348
引用格式: Affinity Biosciences Cat# AF0792, RRID:AB_2834348.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Transcription factor ZBP-89; Transcription factor ZBP89; ZBP89; Zinc finger DNA binding protein 89; Zinc finger DNA-binding protein 89; Zinc finger protein 148; ZN148_HUMAN; ZNF 148; ZNF148;

抗原和靶标

免疫原:
Uniprot:

Q9UQR1(ZN148_HUMAN) >>Visit HPA database.

基因/基因ID:
ZNF148(7707)
描述:
ZNF148 a transcription factor. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes. Belongs to the krueppel C2H2-type zinc-finger protein family.
序列:
MNIDDKLEGLFLKCGGIDEMQSSRTMVVMGGVSGQSTVSGELQDSVLQDRSMPHQEILAADEVLQESEMRQQDMISHDELMVHEETVKNDEEQMETHERLPQGLQYALNVPISVKQEITFTDVSEQLMRDKKQIREPVDLQKKKKRKQRSPAKILTINEDGSLGLKTPKSHVCEHCNAAFRTNYHLQRHVFIHTGEKPFQCSQCDMRFIQKYLLQRHEKIHTGEKPFRCDECGMRFIQKYHMERHKRTHSGEKPYQCEYCLQYFSRTDRVLKHKRMCHENHDKKLNRCAIKGGLLTSEEDSGFSTSPKDNSLPKKKRQKTEKKSSGMDKESALDKSDLKKDKNDYLPLYSSSTKVKDEYMVAEYAVEMPHSSVGGSHLEDASGEIHPPKLVLKKINSKRSLKQPLEQNQTISPLSTYEESKVSKYAFELVDKQALLDSEGNADIDQVDNLQEGPSKPVHSSTNYDDAMQFLKKKRYLQAASNNSREYALNVGTIASQPSVTQAAVASVIDESTTASILESQALNVEIKSNHDKNVIPDEVLQTLLDHYSHKANGQHEISFSVADTEVTSSISINSSEVPEVTPSENVGSSSQASSSDKANMLQEYSKFLQQALDRTSQNDAYLNSPSLNFVTDNQTLPNQPAFSSIDKQVYATMPINSFRSGMNSPLRTTPDKSHFGLIVGDSQHSFPFSGDETNHASATSTQDFLDQVTSQKKAEAQPVHQAYQMSSFEQPFRAPYHGSRAGIATQFSTANGQVNLRGPGTSAEFSEFPLVNVNDNRAGMTSSPDATTGQTFG

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Horse
100
Bovine
100
Sheep
100
Dog
100
Zebrafish
100
Xenopus
80
Chicken
75
Pig
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q9UQR1 作为底物

Site PTM Type Enzyme
T25 Phosphorylation
T37 Phosphorylation
S51 Phosphorylation
K115 Sumoylation
K132 Sumoylation
S150 Phosphorylation
K153 Ubiquitination
K166 Ubiquitination
T167 Phosphorylation
T194 Phosphorylation
K197 Ubiquitination
S202 Phosphorylation Q13315 (ATM)
T222 Phosphorylation
K239 Sumoylation
K239 Ubiquitination
S250 Phosphorylation
Y259 Phosphorylation
K291 Methylation
K291 Ubiquitination
T296 Phosphorylation
S297 Phosphorylation
S301 Phosphorylation
S304 Phosphorylation
T305 Phosphorylation
S306 Phosphorylation
S311 Phosphorylation
S325 Phosphorylation
S331 Phosphorylation
S336 Phosphorylation
K342 Ubiquitination
Y345 Phosphorylation
Y349 Phosphorylation
K356 Sumoylation
S400 Phosphorylation
K402 Ubiquitination
T410 Phosphorylation
S412 Phosphorylation
S415 Phosphorylation
Y417 Phosphorylation
K421 Ubiquitination
S423 Phosphorylation
K424 Sumoylation
K424 Ubiquitination
Y425 Phosphorylation
K432 Ubiquitination
S438 Phosphorylation
K456 Acetylation
K456 Ubiquitination
K472 Ubiquitination
K533 Ubiquitination
K607 Acetylation
K607 Ubiquitination
S627 Phosphorylation
S661 Phosphorylation
S665 Phosphorylation
T669 Phosphorylation
T670 Phosphorylation
R734 Methylation
S740 Phosphorylation
S749 Phosphorylation
S784 Phosphorylation

研究背景

功能:

Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes.

翻译修饰:

Sumoylated with SUMO2. Desumoylated by SENP3, resulting in the stimulation of transcription of its target genes (By similarity).

细胞定位:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
亚基结构:

Interacts with HNRNPDL. Interacts with the 5FMC complex; the interaction requires association with CHTOP. Interacts with CAVIN1 (By similarity).

蛋白家族:

Belongs to the krueppel C2H2-type zinc-finger protein family.

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