ZNHIT1 Antibody - #DF10015

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产品: ZNHIT1 抗体
货号: DF10015
描述: Rabbit polyclonal antibody to ZNHIT1
应用: WB IHC IF/ICC
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 18 kDa; 18kD(Calculated).
蛋白号: O43257
RRID: AB_2840595

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   规格 价格 库存
 100ul RMB¥ 2300 现货
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MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
预测:
Pig(100%), Bovine(%), Horse(%), Sheep(%), Rabbit(%), Dog(%)
克隆:
Polyclonal
特异性:
ZNHIT1 Antibody detects endogenous levels of total ZNHIT1.
RRID:
AB_2840595
引用格式: Affinity Biosciences Cat# DF10015, RRID:AB_2840595.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CG1I; CGBP1; Cyclin G1 binding protein 1; p18 Hamlet; Zinc finger HIT domain containing protein 1; Zinc finger protein subfamily 4A member 1; zinc finger, HIT type 1; ZNFN4A1;

抗原和靶标

免疫原:
Uniprot:

O43257(ZNHI1_HUMAN) >>Visit HPA database.

基因/基因ID:
ZNHIT1(10467)
表达:
O43257 ZNHI1_HUMAN:

Expressed abundantly in liver, but weakly in skeletal muscle, ovary and small intestine.

序列:
MVEKKTSVRSQDPGQRRVLDRAARQRRINRQLEALENDNFQDDPHAGLPQLGKRLPQFDDDADTGKKKKKTRGDHFKLRFRKNFQALLEEQNLSVAEGPNYLTACAGPPSRPQRPFCAVCGFPSPYTCVSCGARYCTVRCLGTHQETRCLKWTV

种属预测

种属预测:

score>80的预测可信度较高，可尝试用于WB检测。*预测模型主要基于免疫原序列比对，结果仅作参考，不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

功能:

Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity.

翻译修饰:

Phosphorylated on Thr by MAPK11 or MAPK14.

Stres-induced ZNHIT1 is mainly regulated at the level of protein.

细胞定位:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Expressed abundantly in liver, but weakly in skeletal muscle, ovary and small intestine.

亚基结构:

Interacts with MAPK11 and MAPK14. Component of the chromatin-remodeling SRCAP complex composed of at least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, ACTR6 and ZNHIT1. Interacts with NR1D1 and NR2D2. Interacts (via HIT-type zinc finger) with the RUVBL1/ RUVBL2 complex in the presence of ADP.

蛋白家族:

Belongs to the ZNHIT1 family.

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