CACNA1D Antibody - #DF10012

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产品: CACNA1D 抗体
货号: DF10012
描述: Rabbit polyclonal antibody to CACNA1D
应用: WB
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
蛋白号: Q01668
RRID: AB_2840592

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   规格 价格 库存
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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产品描述

来源:
Rabbit
应用:
WB 1:1000-3000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
CACNA1D Antibody detects endogenous levels of total CACNA1D.
RRID:
AB_2840592
引用格式: Affinity Biosciences Cat# DF10012, RRID:AB_2840592.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

alpha-1 polypeptide; CAC1D_HUMAN; CACH3; CACN4; CACNA 1D; Cacna1d; CACNL1A2; Calcium channel; Calcium channel L type alpha 1 polypeptide isoform 2; Calcium channel neuroendocrine/brain type alpha 1 subunit; Calcium channel voltage dependent L type alpha 1; Calcium channel voltage dependent L type alpha 1D subunit; Cav1.3; CCHL1A2; isoform 2; L type; PASNA; SANDD; Voltage dependent L type calcium channel subunit alpha 1D; Voltage gated calcium channel alpha 1 subunit; Voltage gated calcium channel alpha subunit Cav1.3; Voltage gated calcium channel subunit alpha Cav1.3; Voltage-dependent L-type calcium channel subunit alpha-1D; Voltage-gated calcium channel subunit alpha Cav1.3;

抗原和靶标

免疫原:

A synthesized peptide derived from human CACNA1D, corresponding to a region within the internal amino acids.

基因/基因ID:
CACNA1D(776)

研究领域

· Cellular Processes > Cell growth and death > Cellular senescence.   (View pathway)

· Cellular Processes > Cellular community - eukaryotes > Tight junction.   (View pathway)

· Environmental Information Processing > Signal transduction > MAPK signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Calcium signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > cAMP signaling pathway.   (View pathway)

· Human Diseases > Endocrine and metabolic diseases > Type II diabetes mellitus.

· Human Diseases > Neurodegenerative diseases > Alzheimer's disease.

· Human Diseases > Substance dependence > Amphetamine addiction.

· Human Diseases > Cardiovascular diseases > Hypertrophic cardiomyopathy (HCM).

· Human Diseases > Cardiovascular diseases > Arrhythmogenic right ventricular cardiomyopathy (ARVC).

· Human Diseases > Cardiovascular diseases > Dilated cardiomyopathy (DCM).

· Organismal Systems > Circulatory system > Cardiac muscle contraction.   (View pathway)

· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes.   (View pathway)

· Organismal Systems > Circulatory system > Vascular smooth muscle contraction.   (View pathway)

· Organismal Systems > Environmental adaptation > Circadian entrainment.

· Organismal Systems > Nervous system > Retrograde endocannabinoid signaling.   (View pathway)

· Organismal Systems > Nervous system > Glutamatergic synapse.

· Organismal Systems > Nervous system > Cholinergic synapse.

· Organismal Systems > Nervous system > Serotonergic synapse.

· Organismal Systems > Nervous system > GABAergic synapse.

· Organismal Systems > Nervous system > Dopaminergic synapse.

· Organismal Systems > Endocrine system > Insulin secretion.   (View pathway)

· Organismal Systems > Endocrine system > Oxytocin signaling pathway.

· Organismal Systems > Endocrine system > Renin secretion.

· Organismal Systems > Endocrine system > Aldosterone synthesis and secretion.

· Organismal Systems > Digestive system > Carbohydrate digestion and absorption.

文献引用

1). Adiponectin receptor 1-mediated basolateral amygdala-prelimbic cortex circuit regulates methamphetamine-associated memory. Cell reports, 2024 (PubMed: 39661515) [IF=7.5]

Application: WB    Species: Mouse    Sample:

Figure 7. Physical exercise resists MA-induced reward memory formation by up-regulating adiponectin/AdipoR1 signaling and downregulating BLACaMKIIa /PrL circuit activity (A) Experimental schematic of effect of physical exercise on MA-induced CPP. (B) Time spent in MA-conditioning chamber. n = 8 per group. (C) CPP scores. n = 8 per group. (D) Proportion of animals with CPP scores above and below mean CPP scores of 2 mg/kg MA-treated mice. (E) Locomotion heatmap. (F) Calcium activity in PrL-projecting BLA CaMKIIa neurons. n = 5 per group. Scale bar: 20 s, 1% DF/F. (G) Effects of physical exercise on adiponectin/AdipoR1/p-AMPK/Cav1.3 signaling in BLA of MA-conditioned mice. n = 6 mice per group. (H) Experimental schematic examining for the effect of AdipoR1 knockdown in PrL-projecting BLA CaMKIIa neurons on regulation of physical exercise in MAinduced CPP. (I) Time spent in MA-conditioning chamber. n = 8 per group. (J) CPP scores. n = 8 per group. (K) Proportion of animals with CPP scores above and below mean CPP scores of mCherry+running+MA group. (L) Locomotion heatmap. (M) Levels of adiponectin, AdipoR1, p-AMPK, and Cav1.3. n = 6 mice per group. (N) Experimental schematic examining for effect of chemogenetic activation of PrL-projecting BLA CaMKIIa neurons on regulation of exercise in MA-induced CPP. (O) Time spent in MA-conditioning chamber. n = 8 per group. (P) CPP scores. n = 8 per group. (Q) Proportion of animals with CPP scores above and below mean CPP scores of running+vehicle+MA group. (R) Locomotion heatmap. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, and ***p < 0.001. See also Table S1 for statistical analysis.

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