MUC13 Antibody - #AF0465

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产品: MUC13 抗体
货号: AF0465
描述: Rabbit polyclonal antibody to MUC13
应用: WB IHC IF/ICC
反应: Human, Mouse, Rat
分子量: 50kDa; 55kD(Calculated).
蛋白号: Q9H3R2
RRID: AB_2834337

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MS Report
HPLC Report
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说明书
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实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse,Rat
克隆:
Polyclonal
特异性:
MUC13 Antibody detects endogenous levels of total MUC13.
RRID:
AB_2834337
引用格式: Affinity Biosciences Cat# AF0465, RRID:AB_2834337.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

Down-regulated in colon cancer 1; DRCC1; FLJ20063; MUC 13; MUC-13; Muc13; MUC13 Down regulated in colon cancer 1; MUC13_HUMAN; Mucin 13, cell surface associated; Mucin-13; PRO20221; RECC; UNQ6194;

抗原和靶标

免疫原:
Uniprot:

Q9H3R2(MUC13_HUMAN) >>Visit HPA database.

基因/基因ID:
MUC13(56667)
表达:
Q9H3R2 MUC13_HUMAN:

Highly expressed in epithelial tissues, particularly those of the gastrointestinal and respiratory tracts, such as large intestine and trachea, followed by kidney, small intestine, appendix and stomach.

描述:
MUC13 Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling. Homodimer of beta subunits.
序列:
MKAIIHLTLLALLSVNTATNQGNSADAVTTTETATSGPTVAAADTTETNFPETASTTANTPSFPTATSPAPPIISTHSSSTIPTPAPPIISTHSSSTIPIPTAADSESTTNVNSLATSDIITASSPNDGLITMVPSETQSNNEMSPTTEDNQSSGPPTGTALLETSTLNSTGPSNPCQDDPCADNSLCVKLHNTSFCLCLEGYYYNSSTCKKGKVFPGKISVTVSETFDPEEKHSMAYQDLHSEITSLFKDVFGTSVYGQTVILTVSTSLSPRSEMRADDKFVNVTIVTILAETTSDNEKTVTEKINKAIRSSSSNFLNYDLTLRCDYYGCNQTADDCLNGLACDCKSDLQRPNPQSPFCVASSLKCPDACNAQHKQCLIKKSGGAPECACVPGYQEDANGNCQKCAFGYSGLDCKDKFQLILTIVGTIAGIVILSMIIALIVTARSNNKTKHIEEENLIDEDFQNLKLRSTGFTNLGAEGSVFPKVRITASRDSQMQNPYSRHSSMPRPDY

翻译修饰 - Q9H3R2 作为底物

Site PTM Type Enzyme
K308 Ubiquitination
K468 Ubiquitination
S471 Phosphorylation
S482 Phosphorylation
S495 Phosphorylation
Y501 Phosphorylation
S502 Phosphorylation
S506 Phosphorylation
Y512 Phosphorylation

研究背景

功能:

Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.

翻译修饰:

Cleaved into two subunits, alpha and beta, probably between the first EGF domain and the SEA domain. Beta subunit contains the cytoplasmic tail and alpha subunit the extracellular tail. The homooligomerization into dimers is dependent on intrachain disulfide bonds.

Highly N-glycosylated.

细胞定位:

Cell membrane>Single-pass type I membrane protein. Apical cell membrane. Secreted.
Note: Also exists as a soluble form.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Highly expressed in epithelial tissues, particularly those of the gastrointestinal and respiratory tracts, such as large intestine and trachea, followed by kidney, small intestine, appendix and stomach.

亚基结构:

Homodimer of beta subunits.

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