Phospho-TORC2 (Ser171) Antibody - #AF8328

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产品: 磷酸化 TORC2 (Ser171) 抗体
货号: AF8328
描述: Rabbit polyclonal antibody to Phospho-TORC2 (Ser171)
应用: WB IHC
文献验证: WB
反应: Human, Mouse, Rat
预测: Pig, Zebrafish, Bovine, Horse, Rabbit, Dog
蛋白号: Q53ET0
RRID: AB_2840390

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   规格 价格 库存
 100ul RMB¥ 2800 现货
 200ul RMB¥ 3800 现货

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产品描述

来源:
Rabbit
应用:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
Phospho-TORC2 (Ser171) Antibody detects endogenous levels of TORC2 only when phosphorylated at Ser171.
RRID:
AB_2840390
引用格式: Affinity Biosciences Cat# AF8328, RRID:AB_2840390.
偶联:
Unconjugated.
纯化:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

CREB regulated transcription coactivator 2; CREB-regulated transcription coactivator 2; CRTC2; CRTC2_HUMAN; RP11-422P24.6; TORC-2; torc2; Transducer of CREB protein 2; Transducer of regulated cAMP response element-binding protein; Transducer of regulated cAMP response element-binding protein (CREB) 2; Transducer of regulated cAMP response element-binding protein 2; Transducer of regulated CREB protein 2;

抗原和靶标

免疫原:

A synthesized peptide derived from human TORC2 around the phosphorylation site of Ser171.

基因/基因ID:
CRTC2(200186)

研究领域

· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > AMPK signaling pathway.   (View pathway)

· Human Diseases > Endocrine and metabolic diseases > Insulin resistance.

· Human Diseases > Infectious diseases: Viral > HTLV-I infection.

· Organismal Systems > Endocrine system > Glucagon signaling pathway.

文献引用

1). Ursodeoxycholic acid ameliorates hepatic lipid metabolism in LO2 cells by regulating the AKT/mTOR/SREBP-1 signaling pathway. World Journal of Gastroenterology, 2019 (PubMed: 30948912) [IF=4.3]

Application: WB    Species: human    Sample: LO2 cells

Figure 3 |Alteration of CRTC2/SREBP-1 signaling pathway under the condition of ursodeoxycholic acid in oleic acid-induced LO2 cells. A: CRTC2 activityand nSREBP-1 expression detected by Western blot assay.
2). Gestational bisphenol A exposure impairs hepatic lipid metabolism by altering mTOR/CRTC2/SREBP1 in male rat offspring. Human & Experimental Toxicology, 2022 (PubMed: 36137816) [IF=2.7]

Application: WB    Species: Rat    Sample:

Figure 5. Effects of gestational BPA exposure on mTOR/CRTC2 pathway in male offspring. (a) The mRNA levels of mTOR and CRTC2 at PND21. (b) Protein levels of mTOR, p-mTOR, CRTC2 and p-CRTC2 at PND21. (c) The mRNA levels of mTOR and CRTC2 at PND56. (d) Protein levels of mTOR, p-mTOR, CRTC2 and p-CRTC2 at PND56. Western blot bands represent the detection of the protein from four independent tests. The relative intensities were expressed in the bar chart. All data were normalized to β-actin level within the same lane/blot, except for the p-CRTC2: mature CRTC2 ratio and the p-mTOR: mature mTOR ratio. Data were shown as means ± SD and analyzed with One-way ANOVA (n = 6). *p < 0.05 vs. Control.

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