mGluR7 Antibody - #AF0171

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产品: mGluR7 抗体
货号: AF0171
描述: Rabbit polyclonal antibody to mGluR7
应用: WB IHC IF/ICC
文献验证: WB, IF/ICC
反应: Human, Mouse, Rat
预测: Bovine, Horse, Dog
蛋白号: Q14831
RRID: AB_2833364

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   规格 价格 库存
 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

货期: 当天发货

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MS Report
HPLC Report
MSDS
说明书
COA
实验方案
WB Handbook
IHC Protocol
IF/ICC Protocol

产品描述

来源:
Rabbit
应用:
WB 1:500-1:3000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human, Mouse, Rat
克隆:
Polyclonal
特异性:
mGluR7 Antibody detects endogenous levels of total mGluR7.
RRID:
AB_2833364
引用格式: Affinity Biosciences Cat# AF0171, RRID:AB_2833364.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

FLJ40498; GLUR7; Glutamate receptor metabotropic 7; GPRC1G; GRM7; GRM7_HUMAN; Metabotropic glutamate receptor 7; MGLU7; mGluR7; OTTHUMP00000206961; OTTHUMP00000214674; OTTHUMP00000214675;

抗原和靶标

免疫原:

A synthesized peptide derived from human mGluR7, corresponding to a region within C-terminal amino acids.

基因/基因ID:
GRM7(2917)
描述:
mGluR7 Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. Interacts with PICK1. 5 isoforms of the human protein are produced by alternative splicing.

研究领域

· Environmental Information Processing > Signal transduction > Phospholipase D signaling pathway.   (View pathway)

· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.

· Organismal Systems > Nervous system > Glutamatergic synapse.

文献引用

1). G-alpha interacting protein interacting protein, C terminus 1 regulates epileptogenesis by increasing the expression of metabotropic glutamate receptor 7. CNS neuroscience & therapeutics, 2022 (PubMed: 34676980) [IF=4.8]

Application: WB    Species: Mouse    Sample:

FIGURE 5 Effects of GAIP interacting protein, C terminus 1 (GIPC1) overexpression on the expression of mGluR7. (A, B) Western blotting images for mGluR7 in the hippocampus (A) and temporal cortex (B) of KA-induced epileptic mice and control mice. (C, D) Quantitative analyses showing that in both the hippocampus (C) and the temporal cortex (D), mGluR7 was decreased in epileptic mice compared with that in control mice (n = 6 per group). (E) Co-IP assay result of GIPC1 and mGluR7 in the hippocampus of KA-induced epileptic mice. (F) High-resolution immunofluorescence images for GIPC1 and mGluR7 in KA-induced epileptic mice. GIPC1 (green) and mGluR7 (red) were co-expressed (merged) (scale bar = 10 μm). (G, I) Western blotting images for GIPC1 (G) and mGluR7 (I) at week 4 post-KA injection following AAV vector injection. (H, J) Statistical analyses indicating that GIPC1 was significantly increased in the GIPC1 + KA group compared with that in the KA and Con-GIPC1 + KA groups (H); similarly, mGluR7 expression (J) showed the same difference (n = 5 per group). (K, L) Western blotting results showing that cell membrane mGluR7 in the GIPC1 + KA group was higher than that in the other two groups (n = 5 per group). *p < 0.05, **p < 0.01, and ***p < 0.001 [Colour figure can be viewed at wileyonlinelibrary.com]

Application: IF/ICC    Species: Mouse    Sample:

FIGURE 5 Effects of GAIP interacting protein, C terminus 1 (GIPC1) overexpression on the expression of mGluR7. (A, B) Western blotting images for mGluR7 in the hippocampus (A) and temporal cortex (B) of KA-induced epileptic mice and control mice. (C, D) Quantitative analyses showing that in both the hippocampus (C) and the temporal cortex (D), mGluR7 was decreased in epileptic mice compared with that in control mice (n = 6 per group). (E) Co-IP assay result of GIPC1 and mGluR7 in the hippocampus of KA-induced epileptic mice. (F) High-resolution immunofluorescence images for GIPC1 and mGluR7 in KA-induced epileptic mice. GIPC1 (green) and mGluR7 (red) were co-expressed (merged) (scale bar = 10 μm). (G, I) Western blotting images for GIPC1 (G) and mGluR7 (I) at week 4 post-KA injection following AAV vector injection. (H, J) Statistical analyses indicating that GIPC1 was significantly increased in the GIPC1 + KA group compared with that in the KA and Con-GIPC1 + KA groups (H); similarly, mGluR7 expression (J) showed the same difference (n = 5 per group). (K, L) Western blotting results showing that cell membrane mGluR7 in the GIPC1 + KA group was higher than that in the other two groups (n = 5 per group). *p < 0.05, **p < 0.01, and ***p < 0.001 [Colour figure can be viewed at wileyonlinelibrary.com]
2). Therapeutic potential of alkaloid extract from Codonopsis Radix in alleviating hepatic lipid accumulation: insights into mitochondrial energy metabolism and endoplasmic reticulum stress regulation in NAFLD mice. Chinese Journal of Natural Medicines, 2023 (PubMed: 37407172) [IF=4.0]
3). FAdV-4 induce autophagy via the endoplasmic reticulum stress-related unfolded protein response. Veterinary Microbiology, 2022 (PubMed: 35487017) [IF=2.4]

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