AKAP14 Antibody - #AF0603

(2)  
产品: AKAP14 抗体
货号: AF0603
描述: Rabbit polyclonal antibody to AKAP14
应用: WB IHC IF/ICC
反应: Human
分子量: 23kDa; 23kD(Calculated).
蛋白号: Q86UN6
RRID: AB_2834299

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 50ul RMB¥ 1250 现货
 100ul RMB¥ 2300 现货
 200ul RMB¥ 3000 现货

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human
克隆:
Polyclonal
特异性:
AKAP14 Antibody detects endogenous levels of total AKAP14.
RRID:
AB_2834299
引用格式: Affinity Biosciences Cat# AF0603, RRID:AB_2834299.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

A kinase (PRKA) anchor protein 14; A kinase anchor protein 14; A kinase anchor protein 28 kDa; A-kinase anchoring protein 28; AKAP14; AKAP28; PRKA14; Protein kinase A anchoring protein 14;

抗原和靶标

免疫原:
Uniprot:

Q86UN6(AKA28_HUMAN) >>Visit HPA database.

基因/基因ID:
AKAP14(158798)
表达:
Q86UN6 AKA28_HUMAN:

Present in cilia (at protein level). Expressed in tissues containing axoneme-based organelles (cilia and/or flagella): trachea and testis. Highly expressed in airway cilia.

描述:
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The protein anchors PKA in ciliary axonemes and, in this way, may play a role in regulating ciliary beat frequency. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
序列:
MSETQNSTSQKAMDEDNKAASQTMPNTQDKNYEDELTQVALALVEDVINYAVKIVEEERNPLKNIKWMTHGEFTVEKGLKQIDEYFSKCVSKKCWAHGVEFVERKDLIHSFLYIYYVHWSISTADLPVARISAGTYFTMKVSKTKPPDAPIVVSYVGDHQALVHRPGMVRFRENWQKNLTDAKYSFMESFPFLFNRV

翻译修饰 - Q86UN6 作为底物

Site PTM Type Enzyme
S2 Phosphorylation
T4 Phosphorylation
S7 Phosphorylation
S9 Phosphorylation
S185 Phosphorylation

研究背景

功能:

Binds to type II regulatory subunits of protein kinase A and anchors/targets them.

细胞定位:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Present in cilia (at protein level). Expressed in tissues containing axoneme-based organelles (cilia and/or flagella): trachea and testis. Highly expressed in airway cilia.

亚基结构:

Binds to type II regulatory subunits (RII).

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