产品: OGR1/GPR68 抗体
货号: AF0723
描述: Rabbit polyclonal antibody to OGR1/GPR68
应用: WB IF/ICC
反应: Human, Mouse
预测: Pig, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 40~70 kD; 41kD(Calculated).
蛋白号: Q15743
RRID: AB_2834264

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产品描述

来源:
Rabbit
应用:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: 适用于变性蛋白样本的免疫印迹检测. IHC: 适用于组织样本的石蜡(IHC-p)或冰冻(IHC-f)切片样本的免疫组化/荧光检测. IF/ICC: 适用于细胞样本的荧光检测. ELISA(peptide): 适用于抗原肽的ELISA检测.

反应:
Human,Mouse
预测:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%)
克隆:
Polyclonal
特异性:
OGR1/GPR68 Antibody detects endogenous levels of total OGR1/GPR68.
RRID:
AB_2834264
引用格式: Affinity Biosciences Cat# AF0723, RRID:AB_2834264.
偶联:
Unconjugated.
纯化:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
别名:

展开/折叠

G protein coupled receptor 68; G-protein coupled receptor 68; GPR 12A; GPR 68; GPR12A; Gpr68; MGC111379; MGC156983; OGR 1; OGR-1; OGR1; OGR1_HUMAN; Ovarian cancer G protein coupled receptor 1; Ovarian cancer G-protein coupled receptor 1; Sphingosylphosphorylcholine receptor;

抗原和靶标

免疫原:
Uniprot:
基因/基因ID:
表达:
Q15743 OGR1_HUMAN:

Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system.

描述:
Protein type: Secreted; Secreted, signal peptide Cellular Component: extracellular region
序列:
MGNITADNSSMSCTIDHTIHQTLAPVVYVTVLVVGFPANCLSLYFGYLQIKARNELGVYLCNLTVADLFYICSLPFWLQYVLQHDNWSHGDLSCQVCGILLYENIYISVGFLCCISVDRYLAVAHPFRFHQFRTLKAAVGVSVVIWAKELLTSIYFLMHEEVIEDENQHRVCFEHYPIQAWQRAINYYRFLVGFLFPICLLLASYQGILRAVRRSHGTQKSRKDQIQRLVLSTVVIFLACFLPYHVLLLVRSVWEASCDFAKGVFNAYHFSLLLTSFNCVADPVLYCFVSETTHRDLARLRGACLAFLTCSRTGRAREAYPLGAPEASGKSGAQGEEPELLTKLHPAFQTPNSPGSGGFPTGRLA

种属预测

种属预测:

score>80的预测可信度较高,可尝试用于WB检测。*预测模型主要基于免疫原序列比对,结果仅作参考,不作为质保凭据。

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Rabbit
100
Chicken
73
Xenopus
0
Zebrafish
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

翻译修饰 - Q15743 作为底物

Site PTM Type Enzyme
Y187 Phosphorylation
Y188 Phosphorylation
Y244 Phosphorylation
S328 Phosphorylation
S331 Phosphorylation
S353 Phosphorylation

研究背景

功能:

Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer (By similarity).

细胞定位:

Cell membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
组织特异性:

Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system.

蛋白家族:

Belongs to the G-protein coupled receptor 1 family.

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